Cell type atlas - LYPLA1 - The Human Protein Atlas

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LYPLA1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LYPLA1
Gene descriptionⁱ Full gene name according to HGNC.	Lysophospholipase I
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	44 NX
Lung	44 NX

B-cells	77 NX
Liver	81 NX
Colon	76 NX
Kidney	71 NX

Basal glandular cells	69 NX
Prostate	69 NX

Basal keratinocytes	55 NX
Skin	55 NX

Bipolar cells	34 NX
Eye	34 NX

Cardiomyocytes	58 NX
Heart muscle	58 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	39 NX
Lung	39 NX

Club cells	33 NX
Lung	33 NX

Collecting duct cells	59 NX
Kidney	59 NX

Cone photoreceptor cells	49 NX
Eye	49 NX

Cytotrophoblasts	181 NX
Placenta	181 NX

Distal tubular cells	257 NX
Kidney	257 NX

Ductal cells	75 NX
Pancreas	75 NX

Early spermatids	730 NX
Testis	730 NX

Endothelial cells	72 NX
Prostate	99 NX
Skin	84 NX
Pancreas	75 NX
Placenta	75 NX
Testis	72 NX
Lung	58 NX
Eye	41 NX
Liver	36 NX
Heart muscle	35 NX

Enterocytes	63 NX
Rectum	86 NX
Small intestine	70 NX
Colon	44 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	77 NX
Pancreas	77 NX

Extravillous trophoblasts	256 NX
Placenta	256 NX

Fibroblasts	43 NX
Placenta	51 NX
Prostate	46 NX
Skin	39 NX
Lung	34 NX
Heart muscle	26 NX

Glandular cells	143 NX
Prostate	143 NX

Granulocytes	50 NX
Colon	74 NX
Lung	26 NX

Hepatocytes	103 NX
Liver	103 NX

Hofbauer cells	105 NX
Placenta	105 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	55 NX
Colon	61 NX
Rectum	49 NX

Ito cells	78 NX
Liver	78 NX

Kupffer cells	109 NX
Liver	109 NX

Late spermatids	529 NX
Testis	529 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	78 NX
Testis	97 NX
Prostate	85 NX
Kidney	83 NX
Skin	80 NX
Lung	61 NX
Pancreas	59 NX

Melanocytes	71 NX
Skin	71 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	60 NX
Pancreas	60 NX

Mucus-secreting cells	73 NX
Rectum	78 NX
Small intestine	68 NX
Colon	60 NX

Muller glia cells	26 NX
Eye	26 NX

Pancreatic endocrine cells	95 NX
Pancreas	95 NX

Paneth cells	67 NX
Small intestine	88 NX
Rectum	67 NX
Colon	20 NX

Peritubular cells	22 NX
Testis	22 NX

Proximal tubular cells	145 NX
Kidney	145 NX

Rod photoreceptor cells	63 NX
Eye	63 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	42 NX
Pancreas	62 NX
Prostate	43 NX
Skin	41 NX
Heart muscle	39 NX

Spermatocytes	70 NX
Testis	70 NX

Spermatogonia	177 NX
Testis	177 NX

Suprabasal keratinocytes	71 NX
Skin	71 NX

Syncytiotrophoblasts	280 NX
Placenta	280 NX

T-cells	61 NX
Colon	67 NX
Liver	64 NX
Skin	61 NX
Kidney	61 NX
Prostate	39 NX
Lung	29 NX

Undifferentiated cells	79 NX
Colon	96 NX
Small intestine	79 NX
Rectum	75 NX

Urothelial cells	160 NX
Prostate	160 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.