Cell type atlas - SERP1 - The Human Protein Atlas

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SERP1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SERP1
Gene descriptionⁱ Full gene name according to HGNC.	Stress associated endoplasmic reticulum protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	63 NX
Lung	63 NX

Alveolar cells type 2	140 NX
Lung	140 NX

B-cells	390 NX
Liver	607 NX
Colon	417 NX
Kidney	299 NX

Basal glandular cells	556 NX
Prostate	556 NX

Basal keratinocytes	478 NX
Skin	478 NX

Bipolar cells	73 NX
Eye	73 NX

Cardiomyocytes	38 NX
Heart muscle	38 NX

Cholangiocytes	161 NX
Liver	161 NX

Ciliated cells	157 NX
Lung	157 NX

Club cells	145 NX
Lung	145 NX

Collecting duct cells	164 NX
Kidney	164 NX

Cone photoreceptor cells	55 NX
Eye	55 NX

Cytotrophoblasts	242 NX
Placenta	242 NX

Distal tubular cells	310 NX
Kidney	310 NX

Ductal cells	208 NX
Pancreas	208 NX

Early spermatids	288 NX
Testis	287 NX

Endothelial cells	160 NX
Prostate	393 NX
Liver	229 NX
Skin	227 NX
Testis	185 NX
Placenta	160 NX
Pancreas	150 NX
Eye	139 NX
Heart muscle	75 NX
Lung	53 NX

Enterocytes	300 NX
Colon	400 NX
Small intestine	288 NX
Rectum	241 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	263 NX
Pancreas	263 NX

Extravillous trophoblasts	395 NX
Placenta	395 NX

Fibroblasts	209 NX
Prostate	568 NX
Skin	234 NX
Placenta	207 NX
Heart muscle	132 NX
Lung	121 NX

Glandular cells	632 NX
Prostate	632 NX

Granulocytes	220 NX
Colon	331 NX
Lung	109 NX

Hepatocytes	431 NX
Liver	431 NX

Hofbauer cells	346 NX
Placenta	346 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	244 NX
Colon	302 NX
Rectum	185 NX

Ito cells	217 NX
Liver	217 NX

Kupffer cells	540 NX
Liver	540 NX

Late spermatids	505 NX
Testis	505 NX

Leydig cells	203 NX
Testis	203 NX

Macrophages	389 NX
Prostate	776 NX
Kidney	634 NX
Testis	561 NX
Skin	370 NX
Pancreas	332 NX
Lung	142 NX

Melanocytes	331 NX
Skin	331 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	233 NX
Pancreas	233 NX

Mucus-secreting cells	362 NX
Colon	791 NX
Rectum	402 NX
Small intestine	295 NX

Muller glia cells	115 NX
Eye	115 NX

Pancreatic endocrine cells	332 NX
Pancreas	332 NX

Paneth cells	414 NX
Colon	798 NX
Rectum	414 NX
Small intestine	302 NX

Peritubular cells	179 NX
Testis	179 NX

Proximal tubular cells	242 NX
Kidney	242 NX

Rod photoreceptor cells	65 NX
Eye	65 NX

Sertoli cells	110 NX
Testis	110 NX

Smooth muscle cells	173 NX
Pancreas	396 NX
Prostate	324 NX
Skin	157 NX
Heart muscle	120 NX

Spermatocytes	133 NX
Testis	133 NX

Spermatogonia	83 NX
Testis	83 NX

Suprabasal keratinocytes	518 NX
Skin	518 NX

Syncytiotrophoblasts	790 NX
Placenta	790 NX

T-cells	280 NX
Prostate	715 NX
Skin	342 NX
Colon	330 NX
Kidney	280 NX
Liver	211 NX
Lung	92 NX

Undifferentiated cells	305 NX
Colon	425 NX
Small intestine	305 NX
Rectum	275 NX

Urothelial cells	900 NX
Prostate	900 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.