Cell type atlas - ACAT2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ACAT2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACAT2
Gene descriptionⁱ Full gene name according to HGNC.	Acetyl-CoA acetyltransferase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Exocrine glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (GAMG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Exocrine glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	12 NX
Lung	12 NX

Alveolar cells type 2	36 NX
Lung	36 NX

B-cells	25 NX
Liver	32 NX
Colon	27 NX
Kidney	22 NX

Basal glandular cells	29 NX
Prostate	29 NX

Basal keratinocytes	23 NX
Skin	23 NX

Bipolar cells	14 NX
Eye	14 NX

Cardiomyocytes	1 NX
Heart muscle	1 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	20 NX
Lung	20 NX

Club cells	22 NX
Lung	22 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	44 NX
Placenta	44 NX

Distal tubular cells	60 NX
Kidney	60 NX

Ductal cells	47 NX
Pancreas	47 NX

Early spermatids	169 NX
Testis	169 NX

Endothelial cells	11 NX
Placenta	74 NX
Lung	18 NX
Prostate	13 NX
Eye	12 NX
Testis	12 NX
Skin	10 NX
Pancreas	7 NX
Liver	5 NX
Heart muscle	2 NX

Enterocytes	24 NX
Rectum	30 NX
Colon	29 NX
Small intestine	11 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	156 NX
Pancreas	156 NX

Extravillous trophoblasts	84 NX
Placenta	84 NX

Fibroblasts	23 NX
Placenta	51 NX
Skin	22 NX
Prostate	22 NX
Lung	7 NX
Heart muscle	1 NX

Glandular cells	31 NX
Prostate	31 NX

Granulocytes	13 NX
Lung	16 NX
Colon	9 NX

Hepatocytes	56 NX
Liver	56 NX

Hofbauer cells	47 NX
Placenta	47 NX

Horizontal cells	13 NX
Eye	13 NX

Intestinal endocrine cells	16 NX
Colon	31 NX
Rectum	2 NX

Ito cells	13 NX
Liver	13 NX

Kupffer cells	11 NX
Liver	11 NX

Late spermatids	110 NX
Testis	110 NX

Leydig cells	13 NX
Testis	13 NX

Macrophages	23 NX
Prostate	68 NX
Pancreas	47 NX
Skin	27 NX
Lung	16 NX
Testis	12 NX
Kidney	9 NX

Melanocytes	29 NX
Skin	29 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	93 NX
Pancreas	93 NX

Mucus-secreting cells	21 NX
Small intestine	23 NX
Colon	22 NX
Rectum	18 NX

Muller glia cells	22 NX
Eye	22 NX

Pancreatic endocrine cells	47 NX
Pancreas	47 NX

Paneth cells	18 NX
Colon	49 NX
Rectum	18 NX
Small intestine	11 NX

Peritubular cells	18 NX
Testis	18 NX

Proximal tubular cells	34 NX
Kidney	34 NX

Rod photoreceptor cells	20 NX
Eye	20 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	34 NX
Pancreas	114 NX
Skin	35 NX
Prostate	23 NX
Heart muscle	3 NX

Spermatocytes	15 NX
Testis	15 NX

Spermatogonia	49 NX
Testis	49 NX

Suprabasal keratinocytes	18 NX
Skin	18 NX

Syncytiotrophoblasts	29 NX
Placenta	29 NX

T-cells	27 NX
Prostate	44 NX
Kidney	38 NX
Skin	27 NX
Colon	26 NX
Liver	24 NX
Lung	22 NX

Undifferentiated cells	23 NX
Colon	38 NX
Small intestine	22 NX
Rectum	20 NX

Urothelial cells	28 NX
Prostate	28 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.