Cell type atlas - KDSR - The Human Protein Atlas

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KDSR

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KDSR
Gene descriptionⁱ Full gene name according to HGNC.	3-ketodihydrosphingosine reductase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	41 NX
Lung	41 NX

B-cells	40 NX
Kidney	54 NX
Colon	39 NX
Liver	27 NX

Basal glandular cells	112 NX
Prostate	112 NX

Basal keratinocytes	141 NX
Skin	141 NX

Bipolar cells	36 NX
Eye	36 NX

Cardiomyocytes	22 NX
Heart muscle	22 NX

Cholangiocytes	69 NX
Liver	69 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	49 NX
Lung	49 NX

Collecting duct cells	37 NX
Kidney	37 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	53 NX
Placenta	53 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	45 NX
Pancreas	45 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	36 NX
Skin	66 NX
Prostate	65 NX
Testis	42 NX
Liver	36 NX
Eye	34 NX
Heart muscle	30 NX
Placenta	29 NX
Pancreas	22 NX
Lung	18 NX

Enterocytes	29 NX
Small intestine	40 NX
Rectum	40 NX
Colon	21 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	32 NX
Pancreas	32 NX

Extravillous trophoblasts	58 NX
Placenta	58 NX

Fibroblasts	54 NX
Prostate	121 NX
Skin	75 NX
Lung	55 NX
Heart muscle	40 NX
Placenta	28 NX

Glandular cells	62 NX
Prostate	62 NX

Granulocytes	25 NX
Colon	28 NX
Lung	23 NX

Hepatocytes	77 NX
Liver	77 NX

Hofbauer cells	32 NX
Placenta	32 NX

Horizontal cells	38 NX
Eye	38 NX

Intestinal endocrine cells	20 NX
Rectum	26 NX
Colon	14 NX

Ito cells	45 NX
Liver	45 NX

Kupffer cells	25 NX
Liver	25 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	66 NX
Testis	66 NX

Macrophages	36 NX
Prostate	46 NX
Skin	39 NX
Testis	39 NX
Lung	34 NX
Pancreas	33 NX
Kidney	27 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	31 NX
Pancreas	31 NX

Mucus-secreting cells	31 NX
Small intestine	35 NX
Rectum	30 NX
Colon	18 NX

Muller glia cells	58 NX
Eye	58 NX

Pancreatic endocrine cells	42 NX
Pancreas	42 NX

Paneth cells	46 NX
Colon	46 NX
Rectum	46 NX
Small intestine	28 NX

Peritubular cells	66 NX
Testis	66 NX

Proximal tubular cells	37 NX
Kidney	37 NX

Rod photoreceptor cells	41 NX
Eye	41 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	42 NX
Prostate	68 NX
Skin	48 NX
Pancreas	37 NX
Heart muscle	25 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	125 NX
Skin	125 NX

Syncytiotrophoblasts	76 NX
Placenta	76 NX

T-cells	20 NX
Skin	112 NX
Colon	26 NX
Lung	25 NX
Kidney	22 NX
Liver	15 NX
Prostate	13 NX

Undifferentiated cells	41 NX
Small intestine	45 NX
Rectum	41 NX
Colon	27 NX

Urothelial cells	95 NX
Prostate	95 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.