Cell type atlas - NDUFA8 - The Human Protein Atlas

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NDUFA8

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFA8
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit A8
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes, Distal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Distal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	30 NX
Lung	30 NX

B-cells	51 NX
Kidney	71 NX
Liver	65 NX
Colon	30 NX

Basal glandular cells	60 NX
Prostate	60 NX

Basal keratinocytes	43 NX
Skin	43 NX

Bipolar cells	43 NX
Eye	43 NX

Cardiomyocytes	528 NX
Heart muscle	528 NX

Cholangiocytes	56 NX
Liver	56 NX

Ciliated cells	70 NX
Lung	70 NX

Club cells	49 NX
Lung	49 NX

Collecting duct cells	79 NX
Kidney	79 NX

Cone photoreceptor cells	28 NX
Eye	28 NX

Cytotrophoblasts	107 NX
Placenta	107 NX

Distal tubular cells	521 NX
Kidney	521 NX

Ductal cells	91 NX
Pancreas	91 NX

Early spermatids	283 NX
Testis	283 NX

Endothelial cells	90 NX
Testis	158 NX
Liver	146 NX
Placenta	139 NX
Heart muscle	120 NX
Pancreas	90 NX
Skin	73 NX
Eye	70 NX
Prostate	67 NX
Lung	53 NX

Enterocytes	103 NX
Small intestine	140 NX
Rectum	81 NX
Colon	73 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	88 NX
Pancreas	88 NX

Extravillous trophoblasts	96 NX
Placenta	96 NX

Fibroblasts	44 NX
Heart muscle	234 NX
Placenta	93 NX
Prostate	44 NX
Skin	34 NX
Lung	29 NX

Glandular cells	75 NX
Prostate	75 NX

Granulocytes	20 NX
Lung	21 NX
Colon	18 NX

Hepatocytes	93 NX
Liver	93 NX

Hofbauer cells	108 NX
Placenta	108 NX

Horizontal cells	43 NX
Eye	43 NX

Intestinal endocrine cells	74 NX
Rectum	77 NX
Colon	71 NX

Ito cells	58 NX
Liver	58 NX

Kupffer cells	41 NX
Liver	41 NX

Late spermatids	68 NX
Testis	68 NX

Leydig cells	52 NX
Testis	52 NX

Macrophages	46 NX
Pancreas	133 NX
Kidney	84 NX
Prostate	50 NX
Skin	40 NX
Testis	39 NX
Lung	35 NX

Melanocytes	89 NX
Skin	89 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	88 NX
Pancreas	88 NX

Mucus-secreting cells	93 NX
Colon	110 NX
Rectum	99 NX
Small intestine	74 NX

Muller glia cells	52 NX
Eye	52 NX

Pancreatic endocrine cells	88 NX
Pancreas	88 NX

Paneth cells	88 NX
Rectum	91 NX
Small intestine	88 NX
Colon	40 NX

Peritubular cells	71 NX
Testis	71 NX

Proximal tubular cells	161 NX
Kidney	161 NX

Rod photoreceptor cells	39 NX
Eye	39 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	57 NX
Heart muscle	155 NX
Pancreas	118 NX
Prostate	57 NX
Skin	47 NX

Spermatocytes	228 NX
Testis	228 NX

Spermatogonia	125 NX
Testis	125 NX

Suprabasal keratinocytes	50 NX
Skin	50 NX

Syncytiotrophoblasts	106 NX
Placenta	106 NX

T-cells	45 NX
Kidney	68 NX
Liver	55 NX
Skin	45 NX
Colon	45 NX
Lung	25 NX
Prostate	22 NX

Undifferentiated cells	119 NX
Colon	146 NX
Rectum	120 NX
Small intestine	106 NX

Urothelial cells	71 NX
Prostate	71 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.