Cell type atlas - CYP20A1 - The Human Protein Atlas

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CYP20A1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CYP20A1
Gene descriptionⁱ Full gene name according to HGNC.	Cytochrome P450 family 20 subfamily A member 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	29 NX
Lung	29 NX

B-cells	33 NX
Colon	111 NX
Liver	29 NX
Kidney	22 NX

Basal glandular cells	35 NX
Prostate	35 NX

Basal keratinocytes	11 NX
Skin	11 NX

Bipolar cells	39 NX
Eye	39 NX

Cardiomyocytes	23 NX
Heart muscle	23 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	28 NX
Lung	28 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	16 NX
Kidney	16 NX

Cone photoreceptor cells	55 NX
Eye	55 NX

Cytotrophoblasts	28 NX
Placenta	28 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	15 NX
Pancreas	15 NX

Early spermatids	79 NX
Testis	79 NX

Endothelial cells	38 NX
Heart muscle	63 NX
Eye	53 NX
Liver	49 NX
Prostate	41 NX
Lung	38 NX
Pancreas	36 NX
Testis	31 NX
Placenta	30 NX
Skin	17 NX

Enterocytes	33 NX
Colon	37 NX
Rectum	34 NX
Small intestine	27 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	18 NX
Pancreas	18 NX

Extravillous trophoblasts	19 NX
Placenta	19 NX

Fibroblasts	34 NX
Heart muscle	75 NX
Placenta	35 NX
Prostate	34 NX
Skin	26 NX
Lung	20 NX

Glandular cells	32 NX
Prostate	32 NX

Granulocytes	28 NX
Lung	37 NX
Colon	18 NX

Hepatocytes	43 NX
Liver	43 NX

Hofbauer cells	34 NX
Placenta	34 NX

Horizontal cells	48 NX
Eye	48 NX

Intestinal endocrine cells	44 NX
Colon	54 NX
Rectum	33 NX

Ito cells	74 NX
Liver	74 NX

Kupffer cells	32 NX
Liver	32 NX

Late spermatids	14 NX
Testis	14 NX

Leydig cells	114 NX
Testis	114 NX

Macrophages	26 NX
Prostate	51 NX
Testis	49 NX
Lung	36 NX
Skin	18 NX
Kidney	16 NX
Pancreas	12 NX

Melanocytes	7 NX
Skin	7 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	22 NX
Pancreas	22 NX

Mucus-secreting cells	30 NX
Colon	34 NX
Small intestine	30 NX
Rectum	23 NX

Muller glia cells	37 NX
Eye	37 NX

Pancreatic endocrine cells	14 NX
Pancreas	14 NX

Paneth cells	28 NX
Colon	29 NX
Small intestine	28 NX
Rectum	26 NX

Peritubular cells	79 NX
Testis	79 NX

Proximal tubular cells	22 NX
Kidney	22 NX

Rod photoreceptor cells	69 NX
Eye	69 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	27 NX
Heart muscle	96 NX
Prostate	46 NX
Skin	22 NX
Pancreas	16 NX

Spermatocytes	43 NX
Testis	43 NX

Spermatogonia	28 NX
Testis	28 NX

Suprabasal keratinocytes	12 NX
Skin	12 NX

Syncytiotrophoblasts	34 NX
Placenta	34 NX

T-cells	33 NX
Prostate	83 NX
Colon	79 NX
Lung	39 NX
Kidney	33 NX
Skin	33 NX
Liver	28 NX

Undifferentiated cells	29 NX
Colon	31 NX
Small intestine	30 NX
Rectum	23 NX

Urothelial cells	28 NX
Prostate	28 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.