Expression of CTSD in glioma - The Human Protein Atlas

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GLIOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

CTSD is not prognostic in glioma

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 189.17
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
3-year survival highⁱ N/A
3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

184.1

Number of samples

153

Samples

Sample	Description	FPKM
TCGA-28-1753-01A	53 years, male, white, alive, 37 days	902.4
TCGA-06-0139-01A	40 years, male, white, dead, 362 days	762.4
TCGA-06-5410-01A	72 years, female, white, dead, 108 days	514.1
TCGA-06-0749-01A	50 years, male, black or african american, dead, 82 days	436.6
TCGA-06-0141-01A	62 years, male, white, dead, 313 days	392.2
TCGA-06-0644-01A	71 years, male, black or african american, dead, 384 days	388.2
TCGA-06-0130-01A	54 years, male, white, dead, 394 days	377.9
TCGA-02-2486-01A	64 years, male, white, dead, 618 days	361.6
TCGA-06-0750-01A	43 years, male, white, dead, 28 days	340.2
TCGA-06-2557-01A	76 years, male, black or african american, dead, 33 days	334.2
TCGA-02-0055-01A	62 years, female, white, dead, 76 days	302.2
TCGA-32-2616-01A	48 years, female, white, dead, 224 days	300.9
TCGA-26-5135-01A	72 years, female, white, dead, 270 days	296.2
TCGA-06-0132-01A	49 years, male, white, dead, 771 days	295.3
TCGA-06-0645-01A	56 years, female, white, dead, 175 days	292.9
TCGA-16-1045-01B	49 years, female, white, dead, 883 days	285.1
TCGA-12-0619-01A	60 years, male, white, dead, 1062 days	284.8
TCGA-76-4929-01A	76 years, female, white, dead, 111 days	278.9
TCGA-41-3915-01A	48 years, male, white, dead, 360 days	277.6
TCGA-06-0649-01B	73 years, female, black or african american, dead, 64 days	266.4
TCGA-32-1980-01A	72 years, male, white, dead, 36 days	262.0
TCGA-12-5299-01A	56 years, female, white, dead, 98 days	257.0
TCGA-06-5412-01A	78 years, female, white, dead, 138 days	256.9
TCGA-06-0745-01A	59 years, male, white, dead, 239 days	244.2
TCGA-26-5132-01A	74 years, male, white, alive, 286 days	243.7
TCGA-06-0878-01A	74 years, male, white, alive, 218 days	241.5
TCGA-41-2571-01A	89 years, male, white, dead, 26 days	241.3
TCGA-19-4065-01A	36 years, male, white, alive, 214 days	241.1
TCGA-28-2513-01A	69 years, female, white, alive, 222 days	239.8
TCGA-14-0789-01A	54 years, male, white, dead, 342 days	239.6
TCGA-06-0184-01A	63 years, male, white, dead, 2126 days	239.1
TCGA-76-4927-01A	58 years, male, white, dead, 535 days	236.8
TCGA-32-4213-01A	47 years, female, white, alive, 604 days	235.1
TCGA-27-2526-01A	79 years, female, white, dead, 87 days	228.7
TCGA-12-5295-01A	60 years, female, white, dead, 454 days	221.9
TCGA-32-2615-01A	62 years, male, white, dead, 485 days	220.3
TCGA-06-0210-01A	72 years, female, white, dead, 225 days	218.5
TCGA-06-0190-01A	62 years, male, white, dead, 317 days	215.2
TCGA-06-0168-01A	59 years, female, white, dead, 598 days	212.2
TCGA-27-2524-01A	56 years, male, white, dead, 231 days	208.7
TCGA-41-4097-01A	63 years, female, white, dead, 6 days	206.2
TCGA-06-5418-01A	75 years, female, white, dead, 83 days	203.7
TCGA-19-2629-01A	60 years, male, white, dead, 737 days	199.6
TCGA-06-0646-01A	61 years, male, white, dead, 175 days	196.9
TCGA-76-4925-01A	76 years, male, white, dead, 146 days	194.6
TCGA-16-0846-01A	85 years, male, white, dead, 119 days	193.9
TCGA-06-0686-01A	53 years, male, white, dead, 432 days	193.7
TCGA-06-0156-01A	57 years, male, white, dead, 178 days	193.6
TCGA-27-2519-01A	48 years, male, white, dead, 550 days	192.8
TCGA-02-2483-01A	43 years, male, asian, alive, 466 days	192.0
TCGA-32-2632-01A	80 years, male, white, dead, 269 days	191.4
TCGA-28-5215-01A	62 years, female, white, dead, 335 days	191.1
TCGA-14-0787-01A	69 years, male, asian, dead, 68 days	190.6
TCGA-28-1747-01C	44 years, male, white, dead, 77 days	189.8
TCGA-32-2638-01A	67 years, male, white, dead, 766 days	188.5
TCGA-28-5208-01A	52 years, male, white, dead, 544 days	188.1
TCGA-06-5859-01A	63 years, male, white, alive, 139 days	186.8
TCGA-06-2564-01A	50 years, male, white, alive, 181 days	185.9
TCGA-06-5856-01A	58 years, male, white, dead, 114 days	181.4
TCGA-06-0882-01A	30 years, male, white, dead, 632 days	179.5
TCGA-06-0187-01A	69 years, male, white, dead, 828 days	179.1
TCGA-06-5411-01A	51 years, male, white, dead, 254 days	177.6
TCGA-41-2572-01A	67 years, male, white, dead, 406 days	177.5
TCGA-06-0138-01A	43 years, male, white, dead, 737 days	175.6
TCGA-26-5136-01B	78 years, female, white, dead, 577 days	175.3
TCGA-06-5858-01A	45 years, female, white, alive, 187 days	170.3
TCGA-14-0817-01A	69 years, female, white, dead, 164 days	167.2
TCGA-19-1787-01B	49 years, male, white, dead, 385 days	167.1
TCGA-76-4928-01B	85 years, female, white, dead, 94 days	166.8
TCGA-08-0386-01A	74 years, male, white, dead, 548 days	165.7
TCGA-12-3650-01A	46 years, male, white, dead, 333 days	165.6
TCGA-28-5213-01A	72 years, male, white, alive, 951 days	165.4
TCGA-06-0747-01A	53 years, male, white, dead, 82 days	163.2
TCGA-12-1597-01B	62 years, female, white, dead, 675 days	163.1
TCGA-06-0219-01A	67 years, male, white, dead, 22 days	162.9
TCGA-14-1823-01A	58 years, female, white, dead, 543 days	161.3
TCGA-19-2625-01A	76 years, female, white, dead, 124 days	161.1
TCGA-19-1390-01A	63 years, female, white, dead, 772 days	159.1
TCGA-12-3653-01A	34 years, female, white, dead, 442 days	158.5
TCGA-27-1830-01A	57 years, male, white, dead, 154 days	156.3
TCGA-06-0158-01A	73 years, male, white, dead, 329 days	156.0
TCGA-28-2499-01A	59 years, male, white, dead, 95 days	155.9
TCGA-14-0781-01B	49 years, male, black or african american, dead, 29 days	154.5
TCGA-27-1834-01A	56 years, male, white, dead, 1233 days	153.6
TCGA-19-2620-01A	70 years, male, white, dead, 148 days	153.3
TCGA-32-2634-01A	82 years, male, white, alive, 693 days	151.6
TCGA-06-5414-01A	61 years, male, white, alive, 273 days	151.2
TCGA-27-1832-01A	59 years, female, white, dead, 300 days	149.8
TCGA-15-0742-01A	65 years, male, white, dead, 419 days	149.2
TCGA-28-2509-01A	77 years, female, white, alive, 145 days	148.3
TCGA-06-0129-01A	30 years, male, asian, dead, 1024 days	147.9
TCGA-06-2562-01A	81 years, male, white, dead, 382 days	146.3
TCGA-06-0178-01A	39 years, male, white, dead, 2681 days	146.2
TCGA-32-5222-01A	66 years, male, white, dead, 585 days	145.2
TCGA-26-5134-01A	74 years, male, white, alive, 167 days	143.0
TCGA-06-2567-01A	65 years, male, white, dead, 133 days	141.5
TCGA-28-5216-01A	52 years, male, white, alive, 415 days	138.1
TCGA-06-5413-01A	67 years, male, white, alive, 268 days	137.7
TCGA-14-1034-01A	60 years, female, dead, 485 days	136.0
TCGA-28-5204-01A	72 years, male, white, dead, 454 days	135.6
TCGA-06-0157-01A	63 years, female, white, dead, 97 days	135.0
TCGA-32-1982-01A	76 years, female, white, dead, 142 days	134.9
TCGA-76-4932-01A	50 years, female, white, dead, 1458 days	131.8
TCGA-06-2561-01A	53 years, female, white, dead, 537 days	129.9
TCGA-06-2559-01A	83 years, male, white, dead, 150 days	127.3
TCGA-27-2528-01A	62 years, male, white, dead, 480 days	127.2
TCGA-06-0174-01A	54 years, male, white, dead, 98 days	127.2
TCGA-26-5133-01A	59 years, male, white, alive, 452 days	126.1
TCGA-12-0821-01A	62 years, male, white, dead, 323 days	125.2
TCGA-26-5139-01A	65 years, female, white, alive, 48 days	125.2
TCGA-06-0743-01A	69 years, male, white, dead, 803 days	124.0
TCGA-12-0616-01A	36 years, female, white, dead, 448 days	123.6
TCGA-15-1444-01A	21 years, male, white, dead, 1537 days	122.3
TCGA-06-0744-01A	67 years, male, white, dead, 1426 days	121.7
TCGA-76-4931-01A	70 years, female, white, dead, 279 days	121.3
TCGA-27-2521-01A	34 years, male, white, dead, 510 days	120.8
TCGA-06-0238-01A	46 years, male, white, dead, 405 days	119.9
TCGA-27-2523-01A	63 years, male, white, dead, 489 days	119.6
TCGA-06-2565-01A	59 years, male, asian, dead, 506 days	119.5
TCGA-12-3652-01A	60 years, male, white, dead, 1062 days	119.4
TCGA-32-1970-01A	59 years, male, white, dead, 468 days	118.3
TCGA-28-5207-01A	71 years, male, white, dead, 343 days	117.4
TCGA-28-5220-01A	67 years, male, white, dead, 388 days	117.3
TCGA-14-2554-01A	52 years, female, white, dead, 532 days	117.1
TCGA-28-5218-01A	63 years, male, white, dead, 157 days	115.7
TCGA-06-2563-01A	72 years, female, white, alive, 932 days	114.7
TCGA-02-0047-01A	78 years, male, white, dead, 448 days	114.6
TCGA-28-2514-01A	45 years, male, asian, alive, 160 days	111.4
TCGA-27-1837-01A	36 years, male, white, dead, 427 days	110.9
TCGA-12-0618-01A	49 years, male, white, dead, 395 days	109.0
TCGA-76-4926-01B	68 years, male, white, dead, 138 days	109.0
TCGA-06-2558-01A	75 years, female, white, dead, 380 days	108.5
TCGA-06-0211-01B	47 years, male, white, dead, 360 days	106.1
TCGA-14-1825-01A	70 years, male, white, dead, 232 days	104.9
TCGA-06-2570-01A	21 years, female, white, alive, 958 days	104.7
TCGA-19-2619-01A	55 years, female, black or african american, alive, 294 days	104.5
TCGA-02-2485-01A	53 years, male, black or african american, alive, 470 days	104.2
TCGA-41-5651-01A	59 years, female, black or african american, dead, 460 days	98.5
TCGA-06-0125-01A	63 years, female, white, dead, 1448 days	92.1
TCGA-27-1835-01A	53 years, female, white, dead, 648 days	91.9
TCGA-28-5209-01A	66 years, female, white, alive, 77 days	91.7
TCGA-14-0790-01B	64 years, female, white, dead, 419 days	86.9
TCGA-06-5416-01A	23 years, female, white, alive, 204 days	86.2
TCGA-26-1442-01A	43 years, male, white, alive, 953 days	85.5
TCGA-06-1804-01A	81 years, female, white, dead, 414 days	85.5
TCGA-19-5960-01A	56 years, male, white, dead, 455 days	85.1
TCGA-06-5408-01A	54 years, female, white, dead, 357 days	84.9
TCGA-27-1831-01A	66 years, male, white, dead, 505 days	78.8
TCGA-19-2624-01A	51 years, male, white, dead, 5 days	73.8
TCGA-14-1829-01A	57 years, male, black or african american, alive, 218 days	69.5
TCGA-14-0871-01A	75 years, female, white, dead, 880 days	64.2
TCGA-06-5417-01A	45 years, female, white, alive, 155 days	54.3
TCGA-06-2569-01A	24 years, female, black or african american, alive, 13 days	40.9
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GLIOMA - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells. Read more	Antibody HPA003001	Antibody CAB000109
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.