Cell type atlas - AKR1A1 - The Human Protein Atlas

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AKR1A1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AKR1A1
Gene descriptionⁱ Full gene name according to HGNC.	Aldo-keto reductase family 1 member A1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	45 NX
Lung	45 NX

Alveolar cells type 2	49 NX
Lung	49 NX

B-cells	133 NX
Kidney	143 NX
Liver	142 NX
Colon	122 NX

Basal glandular cells	81 NX
Prostate	81 NX

Basal keratinocytes	44 NX
Skin	44 NX

Bipolar cells	21 NX
Eye	21 NX

Cardiomyocytes	32 NX
Heart muscle	32 NX

Cholangiocytes	97 NX
Liver	97 NX

Ciliated cells	60 NX
Lung	60 NX

Club cells	53 NX
Lung	53 NX

Collecting duct cells	75 NX
Kidney	75 NX

Cone photoreceptor cells	35 NX
Eye	35 NX

Cytotrophoblasts	94 NX
Placenta	94 NX

Distal tubular cells	154 NX
Kidney	154 NX

Ductal cells	163 NX
Pancreas	163 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	52 NX
Pancreas	82 NX
Placenta	67 NX
Skin	65 NX
Prostate	58 NX
Liver	52 NX
Testis	46 NX
Heart muscle	46 NX
Eye	46 NX
Lung	41 NX

Enterocytes	130 NX
Small intestine	706 NX
Colon	109 NX
Rectum	89 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	137 NX
Pancreas	137 NX

Extravillous trophoblasts	121 NX
Placenta	121 NX

Fibroblasts	80 NX
Placenta	106 NX
Skin	70 NX
Lung	66 NX
Heart muscle	59 NX
Prostate	47 NX

Glandular cells	92 NX
Prostate	92 NX

Granulocytes	109 NX
Lung	116 NX
Colon	101 NX

Hepatocytes	269 NX
Liver	269 NX

Hofbauer cells	347 NX
Placenta	347 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	114 NX
Colon	136 NX
Rectum	91 NX

Ito cells	75 NX
Liver	75 NX

Kupffer cells	111 NX
Liver	111 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	63 NX
Testis	63 NX

Macrophages	160 NX
Pancreas	292 NX
Kidney	219 NX
Prostate	180 NX
Skin	144 NX
Lung	115 NX
Testis	100 NX

Melanocytes	78 NX
Skin	78 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	162 NX
Pancreas	162 NX

Mucus-secreting cells	133 NX
Colon	240 NX
Small intestine	187 NX
Rectum	124 NX

Muller glia cells	27 NX
Eye	27 NX

Pancreatic endocrine cells	119 NX
Pancreas	119 NX

Paneth cells	152 NX
Small intestine	281 NX
Rectum	152 NX
Colon	115 NX

Peritubular cells	53 NX
Testis	53 NX

Proximal tubular cells	1002 NX
Kidney	1002 NX

Rod photoreceptor cells	35 NX
Eye	35 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	50 NX
Pancreas	97 NX
Skin	57 NX
Prostate	41 NX
Heart muscle	26 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	27 NX
Testis	27 NX

Suprabasal keratinocytes	41 NX
Skin	41 NX

Syncytiotrophoblasts	57 NX
Placenta	57 NX

T-cells	53 NX
Kidney	115 NX
Lung	63 NX
Skin	56 NX
Colon	53 NX
Liver	44 NX
Prostate	35 NX

Undifferentiated cells	166 NX
Small intestine	211 NX
Colon	193 NX
Rectum	145 NX

Urothelial cells	98 NX
Prostate	98 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.