Cell type atlas - KDM5B - The Human Protein Atlas

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KDM5B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KDM5B
Gene descriptionⁱ Full gene name according to HGNC.	Lysine demethylase 5B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes, Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes, Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	83 NX
Lung	83 NX

Alveolar cells type 2	33 NX
Lung	33 NX

B-cells	5 NX
Colon	13 NX
Kidney	9 NX
Liver	1 NX

Basal glandular cells	33 NX
Prostate	33 NX

Basal keratinocytes	57 NX
Skin	57 NX

Bipolar cells	31 NX
Eye	31 NX

Cardiomyocytes	7 NX
Heart muscle	7 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	55 NX
Lung	55 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	16 NX
Kidney	16 NX

Cone photoreceptor cells	59 NX
Eye	59 NX

Cytotrophoblasts	36 NX
Placenta	36 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	42 NX
Pancreas	42 NX

Early spermatids	155 NX
Testis	155 NX

Endothelial cells	25 NX
Pancreas	39 NX
Lung	38 NX
Heart muscle	32 NX
Eye	31 NX
Testis	25 NX
Prostate	24 NX
Skin	20 NX
Placenta	19 NX
Liver	7 NX

Enterocytes	16 NX
Colon	21 NX
Rectum	20 NX
Small intestine	13 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	20 NX
Pancreas	20 NX

Extravillous trophoblasts	26 NX
Placenta	26 NX

Fibroblasts	34 NX
Lung	64 NX
Prostate	47 NX
Skin	36 NX
Placenta	28 NX
Heart muscle	24 NX

Glandular cells	40 NX
Prostate	40 NX

Granulocytes	26 NX
Lung	42 NX
Colon	9 NX

Hepatocytes	10 NX
Liver	10 NX

Hofbauer cells	7 NX
Placenta	7 NX

Horizontal cells	14 NX
Eye	14 NX

Intestinal endocrine cells	42 NX
Colon	51 NX
Rectum	33 NX

Ito cells	19 NX
Liver	19 NX

Kupffer cells	18 NX
Liver	18 NX

Late spermatids	181 NX
Testis	181 NX

Leydig cells	34 NX
Testis	34 NX

Macrophages	11 NX
Prostate	33 NX
Skin	16 NX
Lung	14 NX
Testis	11 NX
Kidney	7 NX
Pancreas	7 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	10 NX
Pancreas	10 NX

Mucus-secreting cells	31 NX
Colon	46 NX
Rectum	31 NX
Small intestine	29 NX

Muller glia cells	68 NX
Eye	68 NX

Pancreatic endocrine cells	38 NX
Pancreas	38 NX

Paneth cells	17 NX
Rectum	28 NX
Colon	17 NX
Small intestine	14 NX

Peritubular cells	31 NX
Testis	31 NX

Proximal tubular cells	6 NX
Kidney	6 NX

Rod photoreceptor cells	134 NX
Eye	134 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	22 NX
Heart muscle	55 NX
Pancreas	26 NX
Prostate	22 NX
Skin	15 NX

Spermatocytes	261 NX
Testis	261 NX

Spermatogonia	72 NX
Testis	72 NX

Suprabasal keratinocytes	102 NX
Skin	102 NX

Syncytiotrophoblasts	69 NX
Placenta	69 NX

T-cells	13 NX
Colon	28 NX
Lung	22 NX
Prostate	22 NX
Skin	20 NX
Liver	8 NX
Kidney	5 NX

Undifferentiated cells	27 NX
Colon	34 NX
Rectum	31 NX
Small intestine	13 NX

Urothelial cells	46 NX
Prostate	46 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.