Cell type atlas - SDHB - The Human Protein Atlas

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SDHB

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SDHB
Gene descriptionⁱ Full gene name according to HGNC.	Succinate dehydrogenase complex iron sulfur subunit B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Citric acid cycle related proteins Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	60 NX
Lung	60 NX

Alveolar cells type 2	40 NX
Lung	40 NX

B-cells	77 NX
Liver	100 NX
Kidney	85 NX
Colon	45 NX

Basal glandular cells	79 NX
Prostate	79 NX

Basal keratinocytes	46 NX
Skin	46 NX

Bipolar cells	28 NX
Eye	28 NX

Cardiomyocytes	396 NX
Heart muscle	396 NX

Cholangiocytes	110 NX
Liver	110 NX

Ciliated cells	79 NX
Lung	79 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	45 NX
Kidney	45 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	93 NX
Placenta	93 NX

Distal tubular cells	300 NX
Kidney	300 NX

Ductal cells	104 NX
Pancreas	104 NX

Early spermatids	146 NX
Testis	146 NX

Endothelial cells	54 NX
Pancreas	133 NX
Heart muscle	66 NX
Placenta	60 NX
Testis	55 NX
Prostate	54 NX
Skin	47 NX
Eye	44 NX
Liver	41 NX
Lung	18 NX

Enterocytes	212 NX
Small intestine	255 NX
Rectum	149 NX
Colon	135 NX

Erythroid cells	117 NX
Liver	117 NX

Exocrine glandular cells	131 NX
Pancreas	130 NX

Extravillous trophoblasts	122 NX
Placenta	122 NX

Fibroblasts	59 NX
Heart muscle	160 NX
Placenta	79 NX
Lung	59 NX
Prostate	48 NX
Skin	44 NX

Glandular cells	70 NX
Prostate	70 NX

Granulocytes	66 NX
Colon	83 NX
Lung	49 NX

Hepatocytes	199 NX
Liver	199 NX

Hofbauer cells	163 NX
Placenta	163 NX

Horizontal cells	35 NX
Eye	35 NX

Intestinal endocrine cells	47 NX
Rectum	49 NX
Colon	44 NX

Ito cells	42 NX
Liver	42 NX

Kupffer cells	81 NX
Liver	81 NX

Late spermatids	14 NX
Testis	14 NX

Leydig cells	54 NX
Testis	54 NX

Macrophages	91 NX
Pancreas	206 NX
Kidney	111 NX
Lung	92 NX
Prostate	91 NX
Testis	88 NX
Skin	63 NX

Melanocytes	61 NX
Skin	61 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	125 NX
Pancreas	125 NX

Mucus-secreting cells	90 NX
Colon	110 NX
Rectum	92 NX
Small intestine	73 NX

Muller glia cells	52 NX
Eye	52 NX

Pancreatic endocrine cells	97 NX
Pancreas	97 NX

Paneth cells	193 NX
Small intestine	232 NX
Colon	193 NX
Rectum	169 NX

Peritubular cells	64 NX
Testis	64 NX

Proximal tubular cells	355 NX
Kidney	355 NX

Rod photoreceptor cells	36 NX
Eye	36 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	60 NX
Heart muscle	164 NX
Pancreas	140 NX
Prostate	60 NX
Skin	59 NX

Spermatocytes	86 NX
Testis	86 NX

Spermatogonia	68 NX
Testis	68 NX

Suprabasal keratinocytes	48 NX
Skin	48 NX

Syncytiotrophoblasts	102 NX
Placenta	102 NX

T-cells	52 NX
Kidney	80 NX
Lung	59 NX
Skin	57 NX
Prostate	52 NX
Colon	46 NX
Liver	31 NX

Undifferentiated cells	136 NX
Colon	166 NX
Rectum	136 NX
Small intestine	133 NX

Urothelial cells	97 NX
Prostate	97 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.