Cell type atlas - RRAGC - The Human Protein Atlas

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RRAGC

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RRAGC
Gene descriptionⁱ Full gene name according to HGNC.	Ras related GTP binding C
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	28 NX
Lung	28 NX

B-cells	36 NX
Kidney	54 NX
Liver	35 NX
Colon	30 NX

Basal glandular cells	36 NX
Prostate	36 NX

Basal keratinocytes	100 NX
Skin	100 NX

Bipolar cells	19 NX
Eye	19 NX

Cardiomyocytes	21 NX
Heart muscle	21 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	11 NX
Lung	11 NX

Club cells	11 NX
Lung	11 NX

Collecting duct cells	12 NX
Kidney	12 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	71 NX
Placenta	71 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	46 NX
Pancreas	46 NX

Early spermatids	52 NX
Testis	52 NX

Endothelial cells	21 NX
Prostate	78 NX
Skin	63 NX
Pancreas	29 NX
Liver	25 NX
Placenta	21 NX
Testis	21 NX
Eye	19 NX
Heart muscle	16 NX
Lung	15 NX

Enterocytes	19 NX
Rectum	36 NX
Small intestine	18 NX
Colon	14 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	42 NX
Pancreas	42 NX

Extravillous trophoblasts	50 NX
Placenta	50 NX

Fibroblasts	39 NX
Skin	79 NX
Prostate	56 NX
Placenta	29 NX
Lung	27 NX
Heart muscle	9 NX

Glandular cells	39 NX
Prostate	39 NX

Granulocytes	16 NX
Colon	18 NX
Lung	14 NX

Hepatocytes	10 NX
Liver	10 NX

Hofbauer cells	62 NX
Placenta	62 NX

Horizontal cells	37 NX
Eye	37 NX

Intestinal endocrine cells	14 NX
Rectum	14 NX
Colon	14 NX

Ito cells	38 NX
Liver	38 NX

Kupffer cells	28 NX
Liver	28 NX

Late spermatids	37 NX
Testis	37 NX

Leydig cells	28 NX
Testis	28 NX

Macrophages	38 NX
Prostate	87 NX
Skin	50 NX
Lung	39 NX
Kidney	37 NX
Testis	36 NX
Pancreas	35 NX

Melanocytes	51 NX
Skin	51 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	80 NX
Pancreas	80 NX

Mucus-secreting cells	10 NX
Rectum	14 NX
Small intestine	8 NX
Colon	6 NX

Muller glia cells	40 NX
Eye	40 NX

Pancreatic endocrine cells	39 NX
Pancreas	39 NX

Paneth cells	14 NX
Rectum	16 NX
Colon	14 NX
Small intestine	7 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	24 NX
Kidney	24 NX

Rod photoreceptor cells	21 NX
Eye	21 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	41 NX
Prostate	75 NX
Skin	60 NX
Pancreas	28 NX
Heart muscle	13 NX

Spermatocytes	23 NX
Testis	23 NX

Spermatogonia	25 NX
Testis	25 NX

Suprabasal keratinocytes	123 NX
Skin	123 NX

Syncytiotrophoblasts	187 NX
Placenta	187 NX

T-cells	20 NX
Skin	37 NX
Prostate	26 NX
Liver	22 NX
Kidney	20 NX
Colon	16 NX
Lung	10 NX

Undifferentiated cells	13 NX
Rectum	16 NX
Small intestine	10 NX
Colon	6 NX

Urothelial cells	39 NX
Prostate	39 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.