Cell type atlas - CD58 - The Human Protein Atlas

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CD58

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CD58
Gene descriptionⁱ Full gene name according to HGNC.	CD58 molecule
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	CD markers
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes, Macrophages)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes, Macrophages)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	36 NX
Lung	36 NX

B-cells	12 NX
Colon	31 NX
Kidney	13 NX
Liver	5 NX

Basal glandular cells	13 NX
Prostate	13 NX

Basal keratinocytes	16 NX
Skin	16 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	25 NX
Heart muscle	25 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	34 NX
Lung	34 NX

Club cells	23 NX
Lung	23 NX

Collecting duct cells	14 NX
Kidney	14 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	4 NX
Placenta	4 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	34 NX
Pancreas	34 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	27 NX
Heart muscle	128 NX
Eye	48 NX
Lung	38 NX
Testis	35 NX
Placenta	26 NX
Skin	24 NX
Prostate	22 NX
Liver	20 NX
Pancreas	7 NX

Enterocytes	41 NX
Rectum	56 NX
Small intestine	42 NX
Colon	25 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	25 NX
Pancreas	25 NX

Extravillous trophoblasts	2 NX
Placenta	2 NX

Fibroblasts	16 NX
Heart muscle	118 NX
Skin	28 NX
Placenta	15 NX
Prostate	12 NX
Lung	10 NX

Glandular cells	14 NX
Prostate	14 NX

Granulocytes	50 NX
Lung	81 NX
Colon	18 NX

Hepatocytes	8 NX
Liver	8 NX

Hofbauer cells	58 NX
Placenta	58 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	10 NX
Rectum	14 NX
Colon	7 NX

Ito cells	22 NX
Liver	22 NX

Kupffer cells	34 NX
Liver	34 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	10 NX
Testis	10 NX

Macrophages	115 NX
Pancreas	164 NX
Lung	143 NX
Skin	137 NX
Testis	94 NX
Prostate	69 NX
Kidney	60 NX

Melanocytes	12 NX
Skin	12 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	225 NX
Pancreas	225 NX

Mucus-secreting cells	15 NX
Small intestine	26 NX
Rectum	13 NX
Colon	13 NX

Muller glia cells	4 NX
Eye	4 NX

Pancreatic endocrine cells	31 NX
Pancreas	31 NX

Paneth cells	42 NX
Colon	52 NX
Small intestine	42 NX
Rectum	19 NX

Peritubular cells	11 NX
Testis	11 NX

Proximal tubular cells	24 NX
Kidney	24 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	26 NX
Heart muscle	78 NX
Pancreas	27 NX
Skin	23 NX
Prostate	8 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	24 NX
Skin	24 NX

Syncytiotrophoblasts	2 NX
Placenta	2 NX

T-cells	31 NX
Lung	85 NX
Kidney	47 NX
Colon	46 NX
Skin	37 NX
Prostate	31 NX
Liver	17 NX

Undifferentiated cells	16 NX
Colon	17 NX
Small intestine	16 NX
Rectum	14 NX

Urothelial cells	33 NX
Prostate	33 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.