Cell type atlas - SFPQ - The Human Protein Atlas

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SFPQ

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SFPQ
Gene descriptionⁱ Full gene name according to HGNC.	Splicing factor proline and glutamine rich
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	158 NX
Lung	158 NX

Alveolar cells type 2	234 NX
Lung	234 NX

B-cells	123 NX
Colon	220 NX
Liver	104 NX
Kidney	94 NX

Basal glandular cells	218 NX
Prostate	218 NX

Basal keratinocytes	318 NX
Skin	318 NX

Bipolar cells	223 NX
Eye	223 NX

Cardiomyocytes	127 NX
Heart muscle	127 NX

Cholangiocytes	69 NX
Liver	69 NX

Ciliated cells	123 NX
Lung	123 NX

Club cells	188 NX
Lung	188 NX

Collecting duct cells	105 NX
Kidney	105 NX

Cone photoreceptor cells	181 NX
Eye	181 NX

Cytotrophoblasts	178 NX
Placenta	178 NX

Distal tubular cells	70 NX
Kidney	70 NX

Ductal cells	106 NX
Pancreas	106 NX

Early spermatids	102 NX
Testis	102 NX

Endothelial cells	173 NX
Prostate	235 NX
Skin	222 NX
Eye	198 NX
Lung	196 NX
Heart muscle	170 NX
Pancreas	143 NX
Liver	126 NX
Placenta	113 NX
Testis	112 NX

Enterocytes	93 NX
Colon	195 NX
Small intestine	77 NX
Rectum	63 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	119 NX
Pancreas	119 NX

Extravillous trophoblasts	186 NX
Placenta	186 NX

Fibroblasts	204 NX
Prostate	232 NX
Skin	221 NX
Lung	215 NX
Heart muscle	178 NX
Placenta	112 NX

Glandular cells	134 NX
Prostate	134 NX

Granulocytes	151 NX
Lung	156 NX
Colon	147 NX

Hepatocytes	95 NX
Liver	95 NX

Hofbauer cells	121 NX
Placenta	121 NX

Horizontal cells	162 NX
Eye	162 NX

Intestinal endocrine cells	211 NX
Colon	285 NX
Rectum	136 NX

Ito cells	115 NX
Liver	115 NX

Kupffer cells	123 NX
Liver	123 NX

Late spermatids	250 NX
Testis	250 NX

Leydig cells	132 NX
Testis	132 NX

Macrophages	140 NX
Skin	177 NX
Prostate	149 NX
Lung	147 NX
Kidney	130 NX
Pancreas	115 NX
Testis	99 NX

Melanocytes	133 NX
Skin	133 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	108 NX
Pancreas	108 NX

Mucus-secreting cells	106 NX
Colon	274 NX
Small intestine	124 NX
Rectum	103 NX

Muller glia cells	183 NX
Eye	183 NX

Pancreatic endocrine cells	126 NX
Pancreas	126 NX

Paneth cells	101 NX
Colon	176 NX
Rectum	101 NX
Small intestine	63 NX

Peritubular cells	110 NX
Testis	110 NX

Proximal tubular cells	67 NX
Kidney	67 NX

Rod photoreceptor cells	219 NX
Eye	219 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	201 NX
Skin	260 NX
Prostate	218 NX
Heart muscle	131 NX
Pancreas	119 NX

Spermatocytes	192 NX
Testis	192 NX

Spermatogonia	171 NX
Testis	171 NX

Suprabasal keratinocytes	286 NX
Skin	286 NX

Syncytiotrophoblasts	256 NX
Placenta	256 NX

T-cells	128 NX
Colon	253 NX
Skin	192 NX
Prostate	144 NX
Kidney	128 NX
Lung	124 NX
Liver	86 NX

Undifferentiated cells	134 NX
Colon	274 NX
Small intestine	139 NX
Rectum	107 NX

Urothelial cells	143 NX
Prostate	143 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.