Cell type atlas - CACYBP - The Human Protein Atlas

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CACYBP

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CACYBP
Gene descriptionⁱ Full gene name according to HGNC.	Calcyclin binding protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	80 NX
Lung	80 NX

Alveolar cells type 2	34 NX
Lung	34 NX

B-cells	105 NX
Kidney	107 NX
Colon	103 NX
Liver	88 NX

Basal glandular cells	108 NX
Prostate	108 NX

Basal keratinocytes	104 NX
Skin	104 NX

Bipolar cells	56 NX
Eye	56 NX

Cardiomyocytes	90 NX
Heart muscle	90 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	80 NX
Lung	80 NX

Club cells	52 NX
Lung	52 NX

Collecting duct cells	33 NX
Kidney	33 NX

Cone photoreceptor cells	59 NX
Eye	59 NX

Cytotrophoblasts	185 NX
Placenta	185 NX

Distal tubular cells	129 NX
Kidney	129 NX

Ductal cells	84 NX
Pancreas	84 NX

Early spermatids	76 NX
Testis	76 NX

Endothelial cells	64 NX
Prostate	136 NX
Placenta	96 NX
Pancreas	93 NX
Skin	86 NX
Testis	64 NX
Heart muscle	60 NX
Lung	55 NX
Eye	38 NX
Liver	27 NX

Enterocytes	64 NX
Small intestine	71 NX
Colon	59 NX
Rectum	35 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	83 NX
Pancreas	83 NX

Extravillous trophoblasts	245 NX
Placenta	245 NX

Fibroblasts	121 NX
Skin	142 NX
Prostate	126 NX
Placenta	94 NX
Heart muscle	79 NX
Lung	67 NX

Glandular cells	93 NX
Prostate	93 NX

Granulocytes	91 NX
Colon	119 NX
Lung	63 NX

Hepatocytes	36 NX
Liver	36 NX

Hofbauer cells	172 NX
Placenta	172 NX

Horizontal cells	29 NX
Eye	29 NX

Intestinal endocrine cells	115 NX
Colon	180 NX
Rectum	49 NX

Ito cells	41 NX
Liver	41 NX

Kupffer cells	47 NX
Liver	47 NX

Late spermatids	22 NX
Testis	22 NX

Leydig cells	80 NX
Testis	80 NX

Macrophages	121 NX
Prostate	448 NX
Skin	155 NX
Pancreas	122 NX
Kidney	93 NX
Lung	87 NX
Testis	83 NX

Melanocytes	103 NX
Skin	103 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	342 NX
Pancreas	342 NX

Mucus-secreting cells	43 NX
Colon	170 NX
Small intestine	52 NX
Rectum	43 NX

Muller glia cells	55 NX
Eye	55 NX

Pancreatic endocrine cells	89 NX
Pancreas	89 NX

Paneth cells	53 NX
Small intestine	60 NX
Rectum	53 NX
Colon	46 NX

Peritubular cells	69 NX
Testis	69 NX

Proximal tubular cells	120 NX
Kidney	120 NX

Rod photoreceptor cells	79 NX
Eye	79 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	107 NX
Prostate	150 NX
Pancreas	143 NX
Skin	100 NX
Heart muscle	77 NX

Spermatocytes	101 NX
Testis	101 NX

Spermatogonia	149 NX
Testis	149 NX

Suprabasal keratinocytes	75 NX
Skin	75 NX

Syncytiotrophoblasts	120 NX
Placenta	120 NX

T-cells	115 NX
Prostate	1168 NX
Colon	188 NX
Skin	133 NX
Kidney	115 NX
Lung	79 NX
Liver	71 NX

Undifferentiated cells	82 NX
Colon	211 NX
Small intestine	82 NX
Rectum	54 NX

Urothelial cells	81 NX
Prostate	81 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.