Cell type atlas - PLEKHA3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PLEKHA3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLEKHA3
Gene descriptionⁱ Full gene name according to HGNC.	Pleckstrin homology domain containing A3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	13 NX
Lung	13 NX

B-cells	19 NX
Colon	42 NX
Kidney	22 NX
Liver	15 NX

Basal glandular cells	39 NX
Prostate	39 NX

Basal keratinocytes	38 NX
Skin	38 NX

Bipolar cells	85 NX
Eye	85 NX

Cardiomyocytes	51 NX
Heart muscle	51 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	15 NX
Lung	15 NX

Club cells	10 NX
Lung	10 NX

Collecting duct cells	26 NX
Kidney	26 NX

Cone photoreceptor cells	39 NX
Eye	39 NX

Cytotrophoblasts	24 NX
Placenta	24 NX

Distal tubular cells	66 NX
Kidney	66 NX

Ductal cells	35 NX
Pancreas	35 NX

Early spermatids	146 NX
Testis	146 NX

Endothelial cells	42 NX
Prostate	63 NX
Skin	57 NX
Eye	52 NX
Pancreas	43 NX
Testis	42 NX
Liver	36 NX
Heart muscle	25 NX
Placenta	15 NX
Lung	3 NX

Enterocytes	14 NX
Rectum	19 NX
Small intestine	16 NX
Colon	7 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	41 NX
Pancreas	41 NX

Extravillous trophoblasts	15 NX
Placenta	15 NX

Fibroblasts	24 NX
Prostate	96 NX
Skin	70 NX
Heart muscle	24 NX
Placenta	18 NX
Lung	14 NX

Glandular cells	69 NX
Prostate	69 NX

Granulocytes	10 NX
Lung	12 NX
Colon	9 NX

Hepatocytes	40 NX
Liver	40 NX

Hofbauer cells	15 NX
Placenta	15 NX

Horizontal cells	126 NX
Eye	126 NX

Intestinal endocrine cells	25 NX
Rectum	26 NX
Colon	24 NX

Ito cells	36 NX
Liver	36 NX

Kupffer cells	29 NX
Liver	29 NX

Late spermatids	279 NX
Testis	279 NX

Leydig cells	32 NX
Testis	32 NX

Macrophages	29 NX
Prostate	46 NX
Kidney	34 NX
Testis	30 NX
Skin	29 NX
Pancreas	28 NX
Lung	12 NX

Melanocytes	29 NX
Skin	29 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	26 NX
Pancreas	26 NX

Mucus-secreting cells	21 NX
Colon	23 NX
Rectum	21 NX
Small intestine	20 NX

Muller glia cells	45 NX
Eye	45 NX

Pancreatic endocrine cells	35 NX
Pancreas	35 NX

Paneth cells	12 NX
Rectum	19 NX
Colon	12 NX
Small intestine	0 NX

Peritubular cells	49 NX
Testis	49 NX

Proximal tubular cells	45 NX
Kidney	45 NX

Rod photoreceptor cells	59 NX
Eye	59 NX

Sertoli cells	78 NX
Testis	78 NX

Smooth muscle cells	39 NX
Prostate	91 NX
Skin	71 NX
Pancreas	38 NX
Heart muscle	26 NX

Spermatocytes	64 NX
Testis	64 NX

Spermatogonia	32 NX
Testis	32 NX

Suprabasal keratinocytes	27 NX
Skin	27 NX

Syncytiotrophoblasts	26 NX
Placenta	26 NX

T-cells	26 NX
Prostate	65 NX
Colon	48 NX
Skin	43 NX
Kidney	43 NX
Liver	18 NX
Lung	2 NX

Undifferentiated cells	17 NX
Rectum	18 NX
Small intestine	18 NX
Colon	14 NX

Urothelial cells	54 NX
Prostate	54 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.