Cell type atlas - EPAS1 - The Human Protein Atlas

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EPAS1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EPAS1
Gene descriptionⁱ Full gene name according to HGNC.	Endothelial PAS domain protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Ito cells, Endothelial cells, Syncytiotrophoblasts, Smooth muscle cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (basophil, eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BEWO, BJ hTERT+, HHSteC, RT4, TIME, U-138 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Ito cells, Endothelial cells, Syncytiotrophoblasts, Smooth muscle cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	72 NX
Lung	72 NX

Alveolar cells type 2	138 NX
Lung	138 NX

B-cells	8 NX
Kidney	13 NX
Liver	7 NX
Colon	3 NX

Basal glandular cells	62 NX
Prostate	62 NX

Basal keratinocytes	43 NX
Skin	43 NX

Bipolar cells	4 NX
Eye	4 NX

Cardiomyocytes	59 NX
Heart muscle	59 NX

Cholangiocytes	51 NX
Liver	51 NX

Ciliated cells	31 NX
Lung	31 NX

Club cells	97 NX
Lung	97 NX

Collecting duct cells	4 NX
Kidney	4 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	94 NX
Placenta	94 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	16 NX
Pancreas	15 NX

Early spermatids	13 NX
Testis	13 NX

Endothelial cells	341 NX
Heart muscle	805 NX
Lung	560 NX
Testis	434 NX
Placenta	428 NX
Eye	341 NX
Prostate	277 NX
Liver	259 NX
Skin	208 NX
Pancreas	65 NX

Enterocytes	66 NX
Rectum	129 NX
Colon	80 NX
Small intestine	42 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	46 NX
Pancreas	46 NX

Extravillous trophoblasts	256 NX
Placenta	256 NX

Fibroblasts	105 NX
Placenta	146 NX
Heart muscle	131 NX
Prostate	109 NX
Lung	52 NX
Skin	28 NX

Glandular cells	47 NX
Prostate	47 NX

Granulocytes	40 NX
Colon	46 NX
Lung	35 NX

Hepatocytes	77 NX
Liver	77 NX

Hofbauer cells	48 NX
Placenta	48 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	4 NX
Rectum	5 NX
Colon	3 NX

Ito cells	439 NX
Liver	439 NX

Kupffer cells	58 NX
Liver	58 NX

Late spermatids	42 NX
Testis	42 NX

Leydig cells	12 NX
Testis	12 NX

Macrophages	24 NX
Lung	43 NX
Pancreas	26 NX
Skin	22 NX
Prostate	22 NX
Kidney	14 NX
Testis	4 NX

Melanocytes	27 NX
Skin	27 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	0 NX
Pancreas	0 NX

Mucus-secreting cells	14 NX
Rectum	21 NX
Small intestine	13 NX
Colon	8 NX

Muller glia cells	89 NX
Eye	89 NX

Pancreatic endocrine cells	26 NX
Pancreas	26 NX

Paneth cells	40 NX
Colon	69 NX
Rectum	40 NX
Small intestine	35 NX

Peritubular cells	6 NX
Testis	6 NX

Proximal tubular cells	24 NX
Kidney	24 NX

Rod photoreceptor cells	58 NX
Eye	58 NX

Sertoli cells	278 NX
Testis	278 NX

Smooth muscle cells	281 NX
Prostate	460 NX
Heart muscle	405 NX
Skin	228 NX
Pancreas	19 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	2 NX
Testis	2 NX

Suprabasal keratinocytes	29 NX
Skin	29 NX

Syncytiotrophoblasts	293 NX
Placenta	293 NX

T-cells	10 NX
Colon	32 NX
Skin	22 NX
Lung	14 NX
Kidney	12 NX
Prostate	9 NX
Liver	6 NX

Undifferentiated cells	12 NX
Colon	25 NX
Rectum	19 NX
Small intestine	8 NX

Urothelial cells	58 NX
Prostate	58 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.