Cell type atlas - SOS1 - The Human Protein Atlas

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SOS1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SOS1
Gene descriptionⁱ Full gene name according to HGNC.	SOS Ras/Rac guanine nucleotide exchange factor 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Plasma proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HMC-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	31 NX
Lung	31 NX

B-cells	14 NX
Colon	16 NX
Liver	14 NX
Kidney	13 NX

Basal glandular cells	13 NX
Prostate	13 NX

Basal keratinocytes	18 NX
Skin	18 NX

Bipolar cells	18 NX
Eye	18 NX

Cardiomyocytes	28 NX
Heart muscle	28 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	21 NX
Lung	21 NX

Club cells	19 NX
Lung	19 NX

Collecting duct cells	9 NX
Kidney	9 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	8 NX
Placenta	8 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	8 NX
Pancreas	8 NX

Early spermatids	24 NX
Testis	24 NX

Endothelial cells	33 NX
Heart muscle	71 NX
Lung	47 NX
Eye	41 NX
Testis	38 NX
Prostate	33 NX
Skin	22 NX
Pancreas	18 NX
Placenta	17 NX
Liver	14 NX

Enterocytes	16 NX
Small intestine	25 NX
Rectum	24 NX
Colon	13 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	10 NX
Pancreas	10 NX

Extravillous trophoblasts	7 NX
Placenta	7 NX

Fibroblasts	15 NX
Heart muscle	33 NX
Lung	21 NX
Skin	19 NX
Prostate	14 NX
Placenta	11 NX

Glandular cells	19 NX
Prostate	19 NX

Granulocytes	4 NX
Lung	7 NX
Colon	0 NX

Hepatocytes	15 NX
Liver	15 NX

Hofbauer cells	9 NX
Placenta	9 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	12 NX
Colon	14 NX
Rectum	9 NX

Ito cells	10 NX
Liver	10 NX

Kupffer cells	15 NX
Liver	15 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	21 NX
Testis	21 NX

Macrophages	14 NX
Lung	23 NX
Prostate	16 NX
Kidney	15 NX
Testis	14 NX
Skin	10 NX
Pancreas	0 NX

Melanocytes	7 NX
Skin	7 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	8 NX
Pancreas	8 NX

Mucus-secreting cells	18 NX
Rectum	19 NX
Small intestine	15 NX
Colon	10 NX

Muller glia cells	16 NX
Eye	16 NX

Pancreatic endocrine cells	10 NX
Pancreas	10 NX

Paneth cells	11 NX
Rectum	20 NX
Small intestine	11 NX
Colon	9 NX

Peritubular cells	21 NX
Testis	21 NX

Proximal tubular cells	10 NX
Kidney	10 NX

Rod photoreceptor cells	11 NX
Eye	11 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	11 NX
Heart muscle	38 NX
Skin	12 NX
Prostate	11 NX
Pancreas	4 NX

Spermatocytes	8 NX
Testis	8 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	22 NX
Skin	22 NX

Syncytiotrophoblasts	9 NX
Placenta	9 NX

T-cells	22 NX
Lung	35 NX
Skin	31 NX
Liver	23 NX
Colon	22 NX
Kidney	11 NX
Prostate	0 NX

Undifferentiated cells	16 NX
Rectum	18 NX
Small intestine	16 NX
Colon	5 NX

Urothelial cells	26 NX
Prostate	26 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.