Cell type atlas - DARS - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DARS

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DARS
Gene descriptionⁱ Full gene name according to HGNC.	Aspartyl-tRNA synthetase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	57 NX
Lung	57 NX

Alveolar cells type 2	49 NX
Lung	49 NX

B-cells	70 NX
Colon	82 NX
Liver	67 NX
Kidney	58 NX

Basal glandular cells	90 NX
Prostate	90 NX

Basal keratinocytes	67 NX
Skin	67 NX

Bipolar cells	59 NX
Eye	59 NX

Cardiomyocytes	75 NX
Heart muscle	75 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	48 NX
Lung	48 NX

Club cells	51 NX
Lung	51 NX

Collecting duct cells	44 NX
Kidney	44 NX

Cone photoreceptor cells	31 NX
Eye	31 NX

Cytotrophoblasts	99 NX
Placenta	99 NX

Distal tubular cells	78 NX
Kidney	78 NX

Ductal cells	93 NX
Pancreas	93 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	54 NX
Liver	79 NX
Pancreas	68 NX
Heart muscle	55 NX
Lung	55 NX
Testis	54 NX
Placenta	51 NX
Prostate	50 NX
Skin	50 NX
Eye	43 NX

Enterocytes	21 NX
Rectum	26 NX
Small intestine	22 NX
Colon	18 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	72 NX
Pancreas	72 NX

Extravillous trophoblasts	124 NX
Placenta	124 NX

Fibroblasts	69 NX
Lung	82 NX
Placenta	80 NX
Prostate	69 NX
Heart muscle	60 NX
Skin	57 NX

Glandular cells	66 NX
Prostate	66 NX

Granulocytes	31 NX
Lung	35 NX
Colon	28 NX

Hepatocytes	59 NX
Liver	59 NX

Hofbauer cells	82 NX
Placenta	82 NX

Horizontal cells	51 NX
Eye	51 NX

Intestinal endocrine cells	37 NX
Rectum	47 NX
Colon	27 NX

Ito cells	53 NX
Liver	53 NX

Kupffer cells	79 NX
Liver	79 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	64 NX
Testis	64 NX

Macrophages	52 NX
Testis	76 NX
Skin	59 NX
Lung	54 NX
Prostate	48 NX
Kidney	45 NX
Pancreas	42 NX

Melanocytes	59 NX
Skin	59 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	111 NX
Pancreas	111 NX

Mucus-secreting cells	39 NX
Rectum	44 NX
Colon	35 NX
Small intestine	32 NX

Muller glia cells	84 NX
Eye	84 NX

Pancreatic endocrine cells	78 NX
Pancreas	78 NX

Paneth cells	23 NX
Rectum	48 NX
Colon	23 NX
Small intestine	14 NX

Peritubular cells	72 NX
Testis	72 NX

Proximal tubular cells	75 NX
Kidney	75 NX

Rod photoreceptor cells	24 NX
Eye	24 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	71 NX
Prostate	79 NX
Pancreas	78 NX
Heart muscle	71 NX
Skin	61 NX

Spermatocytes	25 NX
Testis	25 NX

Spermatogonia	45 NX
Testis	45 NX

Suprabasal keratinocytes	63 NX
Skin	63 NX

Syncytiotrophoblasts	114 NX
Placenta	114 NX

T-cells	63 NX
Liver	70 NX
Colon	64 NX
Skin	63 NX
Lung	59 NX
Kidney	57 NX
Prostate	52 NX

Undifferentiated cells	53 NX
Small intestine	59 NX
Colon	50 NX
Rectum	49 NX

Urothelial cells	76 NX
Prostate	76 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.