Cell type atlas - ID2 - The Human Protein Atlas

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ID2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ID2
Gene descriptionⁱ Full gene name according to HGNC.	Inhibitor of DNA binding 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HDLM-2, HEK93)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	131 NX
Lung	131 NX

Alveolar cells type 2	257 NX
Lung	257 NX

B-cells	45 NX
Colon	73 NX
Kidney	45 NX
Liver	30 NX

Basal glandular cells	93 NX
Prostate	93 NX

Basal keratinocytes	117 NX
Skin	117 NX

Bipolar cells	9 NX
Eye	9 NX

Cardiomyocytes	148 NX
Heart muscle	148 NX

Cholangiocytes	273 NX
Liver	273 NX

Ciliated cells	71 NX
Lung	71 NX

Club cells	148 NX
Lung	148 NX

Collecting duct cells	96 NX
Kidney	96 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	219 NX
Placenta	219 NX

Distal tubular cells	471 NX
Kidney	471 NX

Ductal cells	258 NX
Pancreas	258 NX

Early spermatids	11 NX
Testis	11 NX

Endothelial cells	190 NX
Testis	295 NX
Skin	278 NX
Liver	200 NX
Placenta	193 NX
Heart muscle	187 NX
Pancreas	158 NX
Eye	148 NX
Prostate	143 NX
Lung	131 NX

Enterocytes	226 NX
Rectum	334 NX
Colon	295 NX
Small intestine	195 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	138 NX
Pancreas	138 NX

Extravillous trophoblasts	130 NX
Placenta	130 NX

Fibroblasts	270 NX
Prostate	424 NX
Skin	321 NX
Lung	314 NX
Heart muscle	270 NX
Placenta	153 NX

Glandular cells	154 NX
Prostate	154 NX

Granulocytes	916 NX
Lung	1474 NX
Colon	358 NX

Hepatocytes	394 NX
Liver	394 NX

Hofbauer cells	669 NX
Placenta	669 NX

Horizontal cells	6 NX
Eye	6 NX

Intestinal endocrine cells	409 NX
Rectum	438 NX
Colon	381 NX

Ito cells	414 NX
Liver	414 NX

Kupffer cells	337 NX
Liver	337 NX

Late spermatids	15 NX
Testis	15 NX

Leydig cells	115 NX
Testis	115 NX

Macrophages	499 NX
Skin	1371 NX
Prostate	1277 NX
Pancreas	508 NX
Testis	491 NX
Lung	434 NX
Kidney	312 NX

Melanocytes	268 NX
Skin	268 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	3287 NX
Pancreas	3287 NX

Mucus-secreting cells	522 NX
Colon	637 NX
Rectum	581 NX
Small intestine	355 NX

Muller glia cells	479 NX
Eye	479 NX

Pancreatic endocrine cells	95 NX
Pancreas	95 NX

Paneth cells	301 NX
Small intestine	330 NX
Rectum	301 NX
Colon	193 NX

Peritubular cells	31 NX
Testis	31 NX

Proximal tubular cells	191 NX
Kidney	191 NX

Rod photoreceptor cells	24 NX
Eye	24 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	173 NX
Skin	338 NX
Prostate	327 NX
Heart muscle	173 NX
Pancreas	125 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	92 NX
Skin	92 NX

Syncytiotrophoblasts	557 NX
Placenta	557 NX

T-cells	880 NX
Prostate	1578 NX
Skin	884 NX
Lung	881 NX
Liver	855 NX
Kidney	699 NX
Colon	408 NX

Undifferentiated cells	224 NX
Colon	283 NX
Rectum	224 NX
Small intestine	156 NX

Urothelial cells	40 NX
Prostate	40 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.