Cell type atlas - USP34 - The Human Protein Atlas

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USP34

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	USP34
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin specific peptidase 34
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cone photoreceptor cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	60 NX
Lung	60 NX

Alveolar cells type 2	61 NX
Lung	61 NX

B-cells	35 NX
Colon	96 NX
Kidney	31 NX
Liver	27 NX

Basal glandular cells	50 NX
Prostate	50 NX

Basal keratinocytes	54 NX
Skin	54 NX

Bipolar cells	133 NX
Eye	133 NX

Cardiomyocytes	42 NX
Heart muscle	42 NX

Cholangiocytes	56 NX
Liver	56 NX

Ciliated cells	34 NX
Lung	34 NX

Club cells	59 NX
Lung	59 NX

Collecting duct cells	31 NX
Kidney	31 NX

Cone photoreceptor cells	236 NX
Eye	236 NX

Cytotrophoblasts	27 NX
Placenta	27 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	35 NX
Pancreas	35 NX

Early spermatids	108 NX
Testis	108 NX

Endothelial cells	51 NX
Prostate	92 NX
Testis	58 NX
Lung	55 NX
Heart muscle	53 NX
Skin	51 NX
Eye	48 NX
Liver	45 NX
Pancreas	36 NX
Placenta	29 NX

Enterocytes	39 NX
Rectum	39 NX
Colon	39 NX
Small intestine	36 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	29 NX
Pancreas	29 NX

Extravillous trophoblasts	20 NX
Placenta	20 NX

Fibroblasts	45 NX
Prostate	68 NX
Lung	61 NX
Heart muscle	50 NX
Skin	46 NX
Placenta	25 NX

Glandular cells	63 NX
Prostate	63 NX

Granulocytes	31 NX
Lung	35 NX
Colon	28 NX

Hepatocytes	36 NX
Liver	36 NX

Hofbauer cells	20 NX
Placenta	20 NX

Horizontal cells	102 NX
Eye	102 NX

Intestinal endocrine cells	47 NX
Rectum	49 NX
Colon	44 NX

Ito cells	23 NX
Liver	23 NX

Kupffer cells	40 NX
Liver	40 NX

Late spermatids	105 NX
Testis	105 NX

Leydig cells	53 NX
Testis	53 NX

Macrophages	41 NX
Prostate	50 NX
Testis	44 NX
Lung	43 NX
Skin	41 NX
Pancreas	35 NX
Kidney	30 NX

Melanocytes	39 NX
Skin	39 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	31 NX
Pancreas	31 NX

Mucus-secreting cells	32 NX
Small intestine	39 NX
Rectum	33 NX
Colon	31 NX

Muller glia cells	63 NX
Eye	63 NX

Pancreatic endocrine cells	39 NX
Pancreas	39 NX

Paneth cells	38 NX
Small intestine	39 NX
Rectum	38 NX
Colon	35 NX

Peritubular cells	63 NX
Testis	63 NX

Proximal tubular cells	18 NX
Kidney	18 NX

Rod photoreceptor cells	185 NX
Eye	185 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	47 NX
Heart muscle	58 NX
Prostate	57 NX
Skin	47 NX
Pancreas	28 NX

Spermatocytes	98 NX
Testis	98 NX

Spermatogonia	107 NX
Testis	107 NX

Suprabasal keratinocytes	54 NX
Skin	54 NX

Syncytiotrophoblasts	45 NX
Placenta	45 NX

T-cells	41 NX
Lung	71 NX
Colon	64 NX
Skin	46 NX
Kidney	41 NX
Liver	37 NX
Prostate	35 NX

Undifferentiated cells	31 NX
Rectum	34 NX
Small intestine	29 NX
Colon	27 NX

Urothelial cells	58 NX
Prostate	58 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.