Cell type atlas - FN1 - The Human Protein Atlas

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FN1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FN1
Gene descriptionⁱ Full gene name according to HGNC.	Fibronectin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Extravillous trophoblasts, Hepatocytes, Fibroblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Extravillous trophoblasts, Hepatocytes, Fibroblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	63 NX
Lung	63 NX

Alveolar cells type 2	83 NX
Lung	83 NX

B-cells	8 NX
Liver	15 NX
Colon	2 NX
Kidney	0 NX

Basal glandular cells	4 NX
Prostate	4 NX

Basal keratinocytes	49 NX
Skin	49 NX

Bipolar cells	5 NX
Eye	5 NX

Cardiomyocytes	27 NX
Heart muscle	27 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	28 NX
Lung	28 NX

Collecting duct cells	16 NX
Kidney	16 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	52 NX
Placenta	52 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	5 NX
Pancreas	5 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	167 NX
Placenta	850 NX
Lung	327 NX
Eye	271 NX
Skin	235 NX
Testis	167 NX
Heart muscle	167 NX
Prostate	33 NX
Pancreas	29 NX
Liver	5 NX

Enterocytes	0 NX
Rectum	4 NX
Colon	1 NX
Small intestine	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	8 NX
Pancreas	8 NX

Extravillous trophoblasts	2157 NX
Placenta	2157 NX

Fibroblasts	526 NX
Placenta	1300 NX
Heart muscle	533 NX
Skin	514 NX
Lung	216 NX
Prostate	178 NX

Glandular cells	18 NX
Prostate	18 NX

Granulocytes	17 NX
Lung	35 NX
Colon	0 NX

Hepatocytes	963 NX
Liver	963 NX

Hofbauer cells	369 NX
Placenta	368 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	20 NX
Rectum	23 NX
Colon	17 NX

Ito cells	165 NX
Liver	165 NX

Kupffer cells	27 NX
Liver	27 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	173 NX
Testis	173 NX

Macrophages	39 NX
Lung	664 NX
Kidney	83 NX
Skin	45 NX
Testis	37 NX
Pancreas	5 NX
Prostate	5 NX

Melanocytes	105 NX
Skin	105 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	2 NX
Pancreas	2 NX

Mucus-secreting cells	4 NX
Rectum	12 NX
Colon	4 NX
Small intestine	0 NX

Muller glia cells	1 NX
Eye	1 NX

Pancreatic endocrine cells	19 NX
Pancreas	19 NX

Paneth cells	0 NX
Rectum	4 NX
Colon	0 NX
Small intestine	0 NX

Peritubular cells	83 NX
Testis	83 NX

Proximal tubular cells	1 NX
Kidney	1 NX

Rod photoreceptor cells	10 NX
Eye	10 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	163 NX
Pancreas	1625 NX
Heart muscle	291 NX
Prostate	150 NX
Skin	138 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	33 NX
Skin	33 NX

Syncytiotrophoblasts	172 NX
Placenta	172 NX

T-cells	1 NX
Lung	50 NX
Skin	48 NX
Liver	6 NX
Kidney	1 NX
Colon	1 NX
Prostate	0 NX

Undifferentiated cells	4 NX
Rectum	28 NX
Colon	2 NX
Small intestine	0 NX

Urothelial cells	2 NX
Prostate	2 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.