Cell type atlas - POLE4 - The Human Protein Atlas

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POLE4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POLE4
Gene descriptionⁱ Full gene name according to HGNC.	DNA polymerase epsilon 4, accessory subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (NB-4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	36 NX
Lung	36 NX

B-cells	84 NX
Kidney	89 NX
Colon	79 NX
Liver	73 NX

Basal glandular cells	81 NX
Prostate	81 NX

Basal keratinocytes	75 NX
Skin	75 NX

Bipolar cells	22 NX
Eye	22 NX

Cardiomyocytes	41 NX
Heart muscle	41 NX

Cholangiocytes	59 NX
Liver	59 NX

Ciliated cells	35 NX
Lung	35 NX

Club cells	22 NX
Lung	22 NX

Collecting duct cells	70 NX
Kidney	70 NX

Cone photoreceptor cells	41 NX
Eye	41 NX

Cytotrophoblasts	125 NX
Placenta	125 NX

Distal tubular cells	126 NX
Kidney	126 NX

Ductal cells	43 NX
Pancreas	43 NX

Early spermatids	10 NX
Testis	10 NX

Endothelial cells	56 NX
Skin	203 NX
Prostate	138 NX
Testis	114 NX
Placenta	81 NX
Liver	56 NX
Eye	48 NX
Heart muscle	39 NX
Lung	23 NX
Pancreas	22 NX

Enterocytes	119 NX
Small intestine	139 NX
Rectum	134 NX
Colon	72 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	70 NX
Pancreas	70 NX

Extravillous trophoblasts	126 NX
Placenta	126 NX

Fibroblasts	83 NX
Placenta	101 NX
Prostate	92 NX
Skin	83 NX
Heart muscle	30 NX
Lung	23 NX

Glandular cells	82 NX
Prostate	82 NX

Granulocytes	61 NX
Colon	83 NX
Lung	40 NX

Hepatocytes	123 NX
Liver	123 NX

Hofbauer cells	107 NX
Placenta	107 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	12 NX
Rectum	23 NX
Colon	0 NX

Ito cells	69 NX
Liver	69 NX

Kupffer cells	111 NX
Liver	111 NX

Late spermatids	19 NX
Testis	19 NX

Leydig cells	62 NX
Testis	62 NX

Macrophages	91 NX
Kidney	199 NX
Pancreas	166 NX
Skin	111 NX
Testis	85 NX
Prostate	70 NX
Lung	42 NX

Melanocytes	93 NX
Skin	93 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	31 NX
Pancreas	31 NX

Mucus-secreting cells	81 NX
Small intestine	152 NX
Colon	63 NX
Rectum	60 NX

Muller glia cells	78 NX
Eye	78 NX

Pancreatic endocrine cells	62 NX
Pancreas	62 NX

Paneth cells	147 NX
Colon	181 NX
Small intestine	147 NX
Rectum	97 NX

Peritubular cells	51 NX
Testis	51 NX

Proximal tubular cells	126 NX
Kidney	126 NX

Rod photoreceptor cells	105 NX
Eye	105 NX

Sertoli cells	78 NX
Testis	78 NX

Smooth muscle cells	87 NX
Skin	117 NX
Prostate	87 NX
Pancreas	75 NX
Heart muscle	38 NX

Spermatocytes	41 NX
Testis	41 NX

Spermatogonia	87 NX
Testis	87 NX

Suprabasal keratinocytes	85 NX
Skin	85 NX

Syncytiotrophoblasts	79 NX
Placenta	79 NX

T-cells	69 NX
Colon	87 NX
Skin	82 NX
Prostate	74 NX
Kidney	73 NX
Liver	46 NX
Lung	29 NX

Undifferentiated cells	79 NX
Small intestine	85 NX
Colon	81 NX
Rectum	75 NX

Urothelial cells	83 NX
Prostate	83 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.