Cell type atlas - PPM1G - The Human Protein Atlas

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PPM1G

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPM1G
Gene descriptionⁱ Full gene name according to HGNC.	Protein phosphatase, Mg2+/Mn2+ dependent 1G
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	60 NX
Lung	60 NX

Alveolar cells type 2	44 NX
Lung	44 NX

B-cells	61 NX
Colon	78 NX
Liver	63 NX
Kidney	45 NX

Basal glandular cells	65 NX
Prostate	65 NX

Basal keratinocytes	72 NX
Skin	72 NX

Bipolar cells	42 NX
Eye	42 NX

Cardiomyocytes	34 NX
Heart muscle	34 NX

Cholangiocytes	51 NX
Liver	51 NX

Ciliated cells	62 NX
Lung	62 NX

Club cells	66 NX
Lung	66 NX

Collecting duct cells	66 NX
Kidney	66 NX

Cone photoreceptor cells	28 NX
Eye	28 NX

Cytotrophoblasts	71 NX
Placenta	71 NX

Distal tubular cells	28 NX
Kidney	28 NX

Ductal cells	98 NX
Pancreas	98 NX

Early spermatids	1237 NX
Testis	1237 NX

Endothelial cells	66 NX
Prostate	117 NX
Pancreas	97 NX
Testis	80 NX
Eye	78 NX
Placenta	75 NX
Skin	58 NX
Liver	49 NX
Heart muscle	48 NX
Lung	44 NX

Enterocytes	55 NX
Colon	63 NX
Rectum	58 NX
Small intestine	48 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	120 NX
Pancreas	120 NX

Extravillous trophoblasts	140 NX
Placenta	140 NX

Fibroblasts	43 NX
Lung	78 NX
Prostate	61 NX
Placenta	51 NX
Skin	36 NX
Heart muscle	31 NX

Glandular cells	66 NX
Prostate	66 NX

Granulocytes	59 NX
Colon	83 NX
Lung	35 NX

Hepatocytes	38 NX
Liver	38 NX

Hofbauer cells	76 NX
Placenta	76 NX

Horizontal cells	46 NX
Eye	46 NX

Intestinal endocrine cells	77 NX
Colon	92 NX
Rectum	63 NX

Ito cells	36 NX
Liver	36 NX

Kupffer cells	49 NX
Liver	49 NX

Late spermatids	2468 NX
Testis	2468 NX

Leydig cells	65 NX
Testis	65 NX

Macrophages	65 NX
Testis	91 NX
Lung	74 NX
Skin	62 NX
Kidney	60 NX
Prostate	55 NX
Pancreas	52 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	148 NX
Pancreas	148 NX

Mucus-secreting cells	60 NX
Colon	99 NX
Rectum	51 NX
Small intestine	50 NX

Muller glia cells	65 NX
Eye	65 NX

Pancreatic endocrine cells	122 NX
Pancreas	122 NX

Paneth cells	42 NX
Rectum	67 NX
Small intestine	42 NX
Colon	35 NX

Peritubular cells	67 NX
Testis	67 NX

Proximal tubular cells	48 NX
Kidney	48 NX

Rod photoreceptor cells	35 NX
Eye	35 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	46 NX
Pancreas	98 NX
Prostate	67 NX
Heart muscle	46 NX
Skin	41 NX

Spermatocytes	594 NX
Testis	594 NX

Spermatogonia	323 NX
Testis	323 NX

Suprabasal keratinocytes	70 NX
Skin	70 NX

Syncytiotrophoblasts	44 NX
Placenta	44 NX

T-cells	80 NX
Colon	111 NX
Skin	90 NX
Kidney	80 NX
Lung	76 NX
Liver	76 NX
Prostate	31 NX

Undifferentiated cells	83 NX
Colon	136 NX
Small intestine	83 NX
Rectum	69 NX

Urothelial cells	121 NX
Prostate	121 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.