Cell type atlas - EIF2B4 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

EIF2B4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF2B4
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 2B subunit delta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	12 NX
Lung	12 NX

Alveolar cells type 2	15 NX
Lung	15 NX

B-cells	22 NX
Colon	30 NX
Liver	24 NX
Kidney	9 NX

Basal glandular cells	16 NX
Prostate	16 NX

Basal keratinocytes	32 NX
Skin	32 NX

Bipolar cells	22 NX
Eye	22 NX

Cardiomyocytes	29 NX
Heart muscle	29 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	27 NX
Lung	27 NX

Club cells	18 NX
Lung	18 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	63 NX
Eye	63 NX

Cytotrophoblasts	36 NX
Placenta	36 NX

Distal tubular cells	17 NX
Kidney	17 NX

Ductal cells	27 NX
Pancreas	27 NX

Early spermatids	159 NX
Testis	159 NX

Endothelial cells	21 NX
Heart muscle	35 NX
Skin	23 NX
Testis	22 NX
Prostate	21 NX
Liver	20 NX
Placenta	20 NX
Pancreas	11 NX
Eye	11 NX
Lung	9 NX

Enterocytes	20 NX
Colon	21 NX
Small intestine	19 NX
Rectum	18 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	29 NX
Pancreas	29 NX

Extravillous trophoblasts	21 NX
Placenta	21 NX

Fibroblasts	24 NX
Lung	57 NX
Skin	25 NX
Placenta	24 NX
Heart muscle	23 NX
Prostate	18 NX

Glandular cells	17 NX
Prostate	17 NX

Granulocytes	30 NX
Lung	42 NX
Colon	18 NX

Hepatocytes	31 NX
Liver	31 NX

Hofbauer cells	22 NX
Placenta	21 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	23 NX
Rectum	26 NX
Colon	20 NX

Ito cells	23 NX
Liver	23 NX

Kupffer cells	22 NX
Liver	22 NX

Late spermatids	200 NX
Testis	200 NX

Leydig cells	22 NX
Testis	22 NX

Macrophages	20 NX
Pancreas	33 NX
Skin	27 NX
Lung	20 NX
Kidney	20 NX
Testis	19 NX
Prostate	11 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	33 NX
Pancreas	33 NX

Mucus-secreting cells	20 NX
Colon	29 NX
Rectum	21 NX
Small intestine	16 NX

Muller glia cells	23 NX
Eye	23 NX

Pancreatic endocrine cells	24 NX
Pancreas	24 NX

Paneth cells	18 NX
Colon	37 NX
Rectum	18 NX
Small intestine	18 NX

Peritubular cells	23 NX
Testis	23 NX

Proximal tubular cells	23 NX
Kidney	23 NX

Rod photoreceptor cells	57 NX
Eye	57 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	34 NX
Pancreas	37 NX
Heart muscle	36 NX
Skin	30 NX
Prostate	27 NX

Spermatocytes	52 NX
Testis	52 NX

Spermatogonia	36 NX
Testis	36 NX

Suprabasal keratinocytes	31 NX
Skin	31 NX

Syncytiotrophoblasts	39 NX
Placenta	39 NX

T-cells	26 NX
Lung	45 NX
Colon	32 NX
Skin	26 NX
Kidney	24 NX
Liver	23 NX
Prostate	18 NX

Undifferentiated cells	17 NX
Rectum	17 NX
Colon	17 NX
Small intestine	16 NX

Urothelial cells	13 NX
Prostate	13 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.