Cell type atlas - NCL - The Human Protein Atlas

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NCL

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NCL
Gene descriptionⁱ Full gene name according to HGNC.	Nucleolin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	271 NX
Lung	271 NX

Alveolar cells type 2	358 NX
Lung	358 NX

B-cells	280 NX
Colon	324 NX
Liver	311 NX
Kidney	236 NX

Basal glandular cells	370 NX
Prostate	370 NX

Basal keratinocytes	409 NX
Skin	409 NX

Bipolar cells	137 NX
Eye	137 NX

Cardiomyocytes	291 NX
Heart muscle	291 NX

Cholangiocytes	138 NX
Liver	138 NX

Ciliated cells	385 NX
Lung	385 NX

Club cells	589 NX
Lung	589 NX

Collecting duct cells	185 NX
Kidney	185 NX

Cone photoreceptor cells	45 NX
Eye	45 NX

Cytotrophoblasts	333 NX
Placenta	333 NX

Distal tubular cells	196 NX
Kidney	196 NX

Ductal cells	174 NX
Pancreas	173 NX

Early spermatids	15 NX
Testis	15 NX

Endothelial cells	229 NX
Prostate	470 NX
Lung	423 NX
Pancreas	254 NX
Placenta	229 NX
Skin	215 NX
Heart muscle	212 NX
Eye	188 NX
Liver	184 NX
Testis	164 NX

Enterocytes	106 NX
Colon	155 NX
Small intestine	105 NX
Rectum	73 NX

Erythroid cells	210 NX
Liver	210 NX

Exocrine glandular cells	219 NX
Pancreas	219 NX

Extravillous trophoblasts	336 NX
Placenta	336 NX

Fibroblasts	250 NX
Lung	853 NX
Prostate	428 NX
Heart muscle	300 NX
Placenta	259 NX
Skin	187 NX

Glandular cells	218 NX
Prostate	218 NX

Granulocytes	432 NX
Lung	570 NX
Colon	294 NX

Hepatocytes	218 NX
Liver	218 NX

Hofbauer cells	214 NX
Placenta	214 NX

Horizontal cells	76 NX
Eye	76 NX

Intestinal endocrine cells	192 NX
Colon	255 NX
Rectum	129 NX

Ito cells	123 NX
Liver	123 NX

Kupffer cells	136 NX
Liver	136 NX

Late spermatids	19 NX
Testis	19 NX

Leydig cells	201 NX
Testis	201 NX

Macrophages	195 NX
Lung	434 NX
Kidney	229 NX
Skin	186 NX
Pancreas	176 NX
Testis	169 NX
Prostate	162 NX

Melanocytes	157 NX
Skin	157 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	238 NX
Pancreas	238 NX

Mucus-secreting cells	193 NX
Colon	505 NX
Rectum	181 NX
Small intestine	144 NX

Muller glia cells	194 NX
Eye	194 NX

Pancreatic endocrine cells	214 NX
Pancreas	214 NX

Paneth cells	138 NX
Rectum	177 NX
Colon	138 NX
Small intestine	102 NX

Peritubular cells	150 NX
Testis	150 NX

Proximal tubular cells	209 NX
Kidney	209 NX

Rod photoreceptor cells	126 NX
Eye	126 NX

Sertoli cells	149 NX
Testis	149 NX

Smooth muscle cells	282 NX
Prostate	429 NX
Heart muscle	335 NX
Pancreas	282 NX
Skin	259 NX

Spermatocytes	390 NX
Testis	390 NX

Spermatogonia	564 NX
Testis	564 NX

Suprabasal keratinocytes	386 NX
Skin	386 NX

Syncytiotrophoblasts	317 NX
Placenta	317 NX

T-cells	226 NX
Lung	505 NX
Prostate	414 NX
Colon	380 NX
Kidney	252 NX
Skin	226 NX
Liver	150 NX

Undifferentiated cells	269 NX
Colon	462 NX
Small intestine	295 NX
Rectum	229 NX

Urothelial cells	322 NX
Prostate	322 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.