Cell type atlas - ATP6V1A - The Human Protein Atlas

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ATP6V1A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP6V1A
Gene descriptionⁱ Full gene name according to HGNC.	ATPase H+ transporting V1 subunit A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	28 NX
Lung	28 NX

B-cells	29 NX
Liver	32 NX
Colon	30 NX
Kidney	13 NX

Basal glandular cells	13 NX
Prostate	13 NX

Basal keratinocytes	27 NX
Skin	27 NX

Bipolar cells	93 NX
Eye	93 NX

Cardiomyocytes	8 NX
Heart muscle	8 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	15 NX
Lung	15 NX

Club cells	19 NX
Lung	19 NX

Collecting duct cells	94 NX
Kidney	94 NX

Cone photoreceptor cells	39 NX
Eye	39 NX

Cytotrophoblasts	18 NX
Placenta	18 NX

Distal tubular cells	70 NX
Kidney	70 NX

Ductal cells	25 NX
Pancreas	25 NX

Early spermatids	468 NX
Testis	468 NX

Endothelial cells	26 NX
Pancreas	32 NX
Testis	30 NX
Skin	27 NX
Liver	27 NX
Placenta	25 NX
Heart muscle	23 NX
Prostate	20 NX
Eye	19 NX
Lung	12 NX

Enterocytes	24 NX
Rectum	51 NX
Small intestine	24 NX
Colon	21 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	24 NX
Pancreas	24 NX

Extravillous trophoblasts	19 NX
Placenta	19 NX

Fibroblasts	18 NX
Skin	22 NX
Placenta	18 NX
Prostate	14 NX
Lung	12 NX
Heart muscle	8 NX

Glandular cells	28 NX
Prostate	28 NX

Granulocytes	10 NX
Lung	12 NX
Colon	9 NX

Hepatocytes	64 NX
Liver	64 NX

Hofbauer cells	68 NX
Placenta	68 NX

Horizontal cells	95 NX
Eye	95 NX

Intestinal endocrine cells	54 NX
Rectum	56 NX
Colon	51 NX

Ito cells	36 NX
Liver	36 NX

Kupffer cells	95 NX
Liver	95 NX

Late spermatids	570 NX
Testis	570 NX

Leydig cells	17 NX
Testis	17 NX

Macrophages	67 NX
Pancreas	117 NX
Prostate	73 NX
Kidney	68 NX
Testis	50 NX
Lung	47 NX
Skin	46 NX

Melanocytes	44 NX
Skin	44 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	50 NX
Pancreas	50 NX

Mucus-secreting cells	26 NX
Rectum	33 NX
Colon	18 NX
Small intestine	15 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	22 NX
Pancreas	22 NX

Paneth cells	25 NX
Rectum	41 NX
Small intestine	25 NX
Colon	17 NX

Peritubular cells	22 NX
Testis	22 NX

Proximal tubular cells	63 NX
Kidney	63 NX

Rod photoreceptor cells	37 NX
Eye	37 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	15 NX
Pancreas	23 NX
Skin	17 NX
Heart muscle	13 NX
Prostate	9 NX

Spermatocytes	25 NX
Testis	25 NX

Spermatogonia	14 NX
Testis	14 NX

Suprabasal keratinocytes	42 NX
Skin	42 NX

Syncytiotrophoblasts	37 NX
Placenta	37 NX

T-cells	17 NX
Colon	33 NX
Prostate	18 NX
Skin	17 NX
Liver	14 NX
Kidney	14 NX
Lung	10 NX

Undifferentiated cells	21 NX
Rectum	31 NX
Small intestine	18 NX
Colon	14 NX

Urothelial cells	21 NX
Prostate	21 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.