Cell type atlas - FRMD4B - The Human Protein Atlas

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FRMD4B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FRMD4B
Gene descriptionⁱ Full gene name according to HGNC.	FERM domain containing 4B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cone photoreceptor cells, Urothelial cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (CACO-2, hTCEpi, hTERT-HME1, HUVEC TERT2, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells, Urothelial cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	66 NX
Lung	66 NX

B-cells	4 NX
Colon	7 NX
Kidney	5 NX
Liver	2 NX

Basal glandular cells	29 NX
Prostate	29 NX

Basal keratinocytes	54 NX
Skin	54 NX

Bipolar cells	14 NX
Eye	14 NX

Cardiomyocytes	28 NX
Heart muscle	28 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	39 NX
Lung	39 NX

Club cells	60 NX
Lung	60 NX

Collecting duct cells	14 NX
Kidney	14 NX

Cone photoreceptor cells	206 NX
Eye	206 NX

Cytotrophoblasts	43 NX
Placenta	43 NX

Distal tubular cells	28 NX
Kidney	28 NX

Ductal cells	26 NX
Pancreas	26 NX

Early spermatids	13 NX
Testis	13 NX

Endothelial cells	60 NX
Pancreas	90 NX
Skin	77 NX
Lung	73 NX
Liver	65 NX
Testis	60 NX
Placenta	57 NX
Eye	47 NX
Prostate	38 NX
Heart muscle	31 NX

Enterocytes	37 NX
Colon	96 NX
Rectum	40 NX
Small intestine	11 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	15 NX
Pancreas	15 NX

Extravillous trophoblasts	15 NX
Placenta	15 NX

Fibroblasts	17 NX
Lung	143 NX
Heart muscle	50 NX
Prostate	17 NX
Skin	17 NX
Placenta	6 NX

Glandular cells	39 NX
Prostate	39 NX

Granulocytes	33 NX
Lung	56 NX
Colon	9 NX

Hepatocytes	42 NX
Liver	42 NX

Hofbauer cells	76 NX
Placenta	76 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	24 NX
Colon	31 NX
Rectum	16 NX

Ito cells	76 NX
Liver	76 NX

Kupffer cells	111 NX
Liver	111 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	6 NX
Testis	6 NX

Macrophages	58 NX
Skin	159 NX
Testis	88 NX
Prostate	52 NX
Lung	46 NX
Kidney	37 NX
Pancreas	28 NX

Melanocytes	27 NX
Skin	27 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	2 NX
Pancreas	2 NX

Mucus-secreting cells	27 NX
Colon	68 NX
Rectum	28 NX
Small intestine	20 NX

Muller glia cells	13 NX
Eye	13 NX

Pancreatic endocrine cells	19 NX
Pancreas	19 NX

Paneth cells	42 NX
Colon	115 NX
Small intestine	42 NX
Rectum	22 NX

Peritubular cells	17 NX
Testis	17 NX

Proximal tubular cells	44 NX
Kidney	44 NX

Rod photoreceptor cells	107 NX
Eye	107 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	6 NX
Prostate	39 NX
Skin	8 NX
Heart muscle	4 NX
Pancreas	1 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	2 NX
Testis	2 NX

Suprabasal keratinocytes	45 NX
Skin	45 NX

Syncytiotrophoblasts	49 NX
Placenta	49 NX

T-cells	19 NX
Lung	63 NX
Skin	55 NX
Prostate	39 NX
Colon	32 NX
Kidney	19 NX
Liver	0 NX

Undifferentiated cells	17 NX
Colon	53 NX
Small intestine	19 NX
Rectum	15 NX

Urothelial cells	174 NX
Prostate	174 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.