Cell type atlas - H2AFY - The Human Protein Atlas

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H2AFY

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	H2AFY
Gene descriptionⁱ Full gene name according to HGNC.	H2A histone family member Y
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	89 NX
Lung	89 NX

Alveolar cells type 2	74 NX
Lung	74 NX

B-cells	95 NX
Liver	103 NX
Colon	97 NX
Kidney	94 NX

Basal glandular cells	104 NX
Prostate	104 NX

Basal keratinocytes	115 NX
Skin	115 NX

Bipolar cells	133 NX
Eye	133 NX

Cardiomyocytes	50 NX
Heart muscle	50 NX

Cholangiocytes	99 NX
Liver	99 NX

Ciliated cells	112 NX
Lung	112 NX

Club cells	114 NX
Lung	114 NX

Collecting duct cells	75 NX
Kidney	75 NX

Cone photoreceptor cells	90 NX
Eye	90 NX

Cytotrophoblasts	126 NX
Placenta	126 NX

Distal tubular cells	61 NX
Kidney	61 NX

Ductal cells	218 NX
Pancreas	218 NX

Early spermatids	40 NX
Testis	40 NX

Endothelial cells	83 NX
Placenta	133 NX
Prostate	128 NX
Eye	116 NX
Pancreas	100 NX
Skin	99 NX
Testis	73 NX
Lung	61 NX
Heart muscle	61 NX
Liver	59 NX

Enterocytes	189 NX
Rectum	200 NX
Small intestine	196 NX
Colon	134 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	111 NX
Pancreas	111 NX

Extravillous trophoblasts	117 NX
Placenta	117 NX

Fibroblasts	70 NX
Placenta	204 NX
Prostate	86 NX
Lung	70 NX
Skin	67 NX
Heart muscle	57 NX

Glandular cells	135 NX
Prostate	135 NX

Granulocytes	51 NX
Colon	55 NX
Lung	47 NX

Hepatocytes	51 NX
Liver	51 NX

Hofbauer cells	384 NX
Placenta	384 NX

Horizontal cells	323 NX
Eye	323 NX

Intestinal endocrine cells	171 NX
Colon	214 NX
Rectum	129 NX

Ito cells	64 NX
Liver	64 NX

Kupffer cells	399 NX
Liver	399 NX

Late spermatids	18 NX
Testis	18 NX

Leydig cells	57 NX
Testis	57 NX

Macrophages	338 NX
Pancreas	456 NX
Prostate	441 NX
Kidney	349 NX
Testis	327 NX
Skin	306 NX
Lung	247 NX

Melanocytes	86 NX
Skin	86 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	167 NX
Pancreas	167 NX

Mucus-secreting cells	190 NX
Colon	245 NX
Rectum	181 NX
Small intestine	163 NX

Muller glia cells	116 NX
Eye	116 NX

Pancreatic endocrine cells	180 NX
Pancreas	180 NX

Paneth cells	157 NX
Small intestine	175 NX
Rectum	157 NX
Colon	156 NX

Peritubular cells	77 NX
Testis	77 NX

Proximal tubular cells	77 NX
Kidney	77 NX

Rod photoreceptor cells	167 NX
Eye	167 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	91 NX
Pancreas	167 NX
Prostate	114 NX
Skin	85 NX
Heart muscle	43 NX

Spermatocytes	52 NX
Testis	52 NX

Spermatogonia	75 NX
Testis	75 NX

Suprabasal keratinocytes	139 NX
Skin	139 NX

Syncytiotrophoblasts	153 NX
Placenta	153 NX

T-cells	98 NX
Skin	120 NX
Kidney	109 NX
Lung	98 NX
Colon	92 NX
Liver	86 NX
Prostate	44 NX

Undifferentiated cells	203 NX
Small intestine	239 NX
Colon	226 NX
Rectum	177 NX

Urothelial cells	196 NX
Prostate	196 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.