Cell type atlas - RARS - The Human Protein Atlas

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RARS

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RARS
Gene descriptionⁱ Full gene name according to HGNC.	Arginyl-tRNA synthetase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	32 NX
Lung	32 NX

B-cells	25 NX
Liver	32 NX
Kidney	22 NX
Colon	18 NX

Basal glandular cells	38 NX
Prostate	38 NX

Basal keratinocytes	26 NX
Skin	26 NX

Bipolar cells	25 NX
Eye	25 NX

Cardiomyocytes	44 NX
Heart muscle	44 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	40 NX
Lung	40 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	89 NX
Placenta	89 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	80 NX
Pancreas	80 NX

Early spermatids	17 NX
Testis	17 NX

Endothelial cells	28 NX
Pancreas	75 NX
Placenta	40 NX
Liver	32 NX
Lung	32 NX
Heart muscle	32 NX
Testis	28 NX
Prostate	27 NX
Skin	18 NX
Eye	17 NX

Enterocytes	41 NX
Small intestine	78 NX
Colon	32 NX
Rectum	31 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	83 NX
Pancreas	83 NX

Extravillous trophoblasts	79 NX
Placenta	79 NX

Fibroblasts	35 NX
Lung	110 NX
Placenta	69 NX
Heart muscle	35 NX
Skin	21 NX
Prostate	20 NX

Glandular cells	25 NX
Prostate	25 NX

Granulocytes	27 NX
Lung	35 NX
Colon	18 NX

Hepatocytes	31 NX
Liver	31 NX

Hofbauer cells	51 NX
Placenta	51 NX

Horizontal cells	13 NX
Eye	13 NX

Intestinal endocrine cells	13 NX
Colon	14 NX
Rectum	12 NX

Ito cells	33 NX
Liver	33 NX

Kupffer cells	25 NX
Liver	25 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	23 NX
Testis	23 NX

Macrophages	35 NX
Pancreas	54 NX
Lung	48 NX
Kidney	37 NX
Testis	33 NX
Skin	19 NX
Prostate	19 NX

Melanocytes	27 NX
Skin	27 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	72 NX
Pancreas	72 NX

Mucus-secreting cells	37 NX
Rectum	40 NX
Colon	40 NX
Small intestine	29 NX

Muller glia cells	23 NX
Eye	23 NX

Pancreatic endocrine cells	61 NX
Pancreas	61 NX

Paneth cells	39 NX
Small intestine	56 NX
Rectum	39 NX
Colon	12 NX

Peritubular cells	23 NX
Testis	23 NX

Proximal tubular cells	36 NX
Kidney	36 NX

Rod photoreceptor cells	23 NX
Eye	23 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	29 NX
Pancreas	118 NX
Heart muscle	30 NX
Prostate	29 NX
Skin	24 NX

Spermatocytes	28 NX
Testis	28 NX

Spermatogonia	42 NX
Testis	42 NX

Suprabasal keratinocytes	31 NX
Skin	31 NX

Syncytiotrophoblasts	71 NX
Placenta	71 NX

T-cells	20 NX
Lung	36 NX
Kidney	25 NX
Liver	20 NX
Colon	20 NX
Prostate	18 NX
Skin	15 NX

Undifferentiated cells	45 NX
Colon	63 NX
Small intestine	49 NX
Rectum	41 NX

Urothelial cells	35 NX
Prostate	35 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.