Cell type atlas - SKP1 - The Human Protein Atlas

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SKP1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SKP1
Gene descriptionⁱ Full gene name according to HGNC.	S-phase kinase associated protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	265 NX
Lung	265 NX

Alveolar cells type 2	270 NX
Lung	270 NX

B-cells	263 NX
Kidney	508 NX
Colon	278 NX
Liver	201 NX

Basal glandular cells	830 NX
Prostate	830 NX

Basal keratinocytes	599 NX
Skin	599 NX

Bipolar cells	220 NX
Eye	220 NX

Cardiomyocytes	653 NX
Heart muscle	653 NX

Cholangiocytes	438 NX
Liver	438 NX

Ciliated cells	570 NX
Lung	570 NX

Club cells	338 NX
Lung	338 NX

Collecting duct cells	564 NX
Kidney	564 NX

Cone photoreceptor cells	69 NX
Eye	69 NX

Cytotrophoblasts	767 NX
Placenta	767 NX

Distal tubular cells	1437 NX
Kidney	1437 NX

Ductal cells	561 NX
Pancreas	561 NX

Early spermatids	416 NX
Testis	416 NX

Endothelial cells	364 NX
Prostate	506 NX
Placenta	486 NX
Pancreas	480 NX
Skin	417 NX
Testis	364 NX
Eye	361 NX
Heart muscle	354 NX
Lung	312 NX
Liver	301 NX

Enterocytes	459 NX
Small intestine	543 NX
Rectum	384 NX
Colon	347 NX

Erythroid cells	491 NX
Liver	491 NX

Exocrine glandular cells	330 NX
Pancreas	330 NX

Extravillous trophoblasts	627 NX
Placenta	627 NX

Fibroblasts	510 NX
Prostate	994 NX
Placenta	556 NX
Heart muscle	520 NX
Skin	431 NX
Lung	416 NX

Glandular cells	662 NX
Prostate	662 NX

Granulocytes	327 NX
Lung	342 NX
Colon	312 NX

Hepatocytes	355 NX
Liver	355 NX

Hofbauer cells	417 NX
Placenta	417 NX

Horizontal cells	211 NX
Eye	211 NX

Intestinal endocrine cells	342 NX
Colon	391 NX
Rectum	293 NX

Ito cells	301 NX
Liver	301 NX

Kupffer cells	284 NX
Liver	284 NX

Late spermatids	774 NX
Testis	774 NX

Leydig cells	557 NX
Testis	557 NX

Macrophages	378 NX
Kidney	471 NX
Skin	424 NX
Prostate	396 NX
Pancreas	372 NX
Testis	294 NX
Lung	290 NX

Melanocytes	682 NX
Skin	682 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	670 NX
Pancreas	670 NX

Mucus-secreting cells	302 NX
Colon	453 NX
Small intestine	338 NX
Rectum	290 NX

Muller glia cells	518 NX
Eye	518 NX

Pancreatic endocrine cells	333 NX
Pancreas	333 NX

Paneth cells	551 NX
Colon	642 NX
Small intestine	551 NX
Rectum	333 NX

Peritubular cells	670 NX
Testis	670 NX

Proximal tubular cells	1024 NX
Kidney	1024 NX

Rod photoreceptor cells	167 NX
Eye	167 NX

Sertoli cells	498 NX
Testis	498 NX

Smooth muscle cells	624 NX
Prostate	893 NX
Heart muscle	624 NX
Skin	598 NX
Pancreas	539 NX

Spermatocytes	685 NX
Testis	685 NX

Spermatogonia	644 NX
Testis	644 NX

Suprabasal keratinocytes	564 NX
Skin	564 NX

Syncytiotrophoblasts	1127 NX
Placenta	1127 NX

T-cells	372 NX
Prostate	697 NX
Kidney	609 NX
Skin	596 NX
Colon	408 NX
Lung	301 NX
Liver	257 NX

Undifferentiated cells	337 NX
Colon	442 NX
Small intestine	345 NX
Rectum	292 NX

Urothelial cells	686 NX
Prostate	686 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.