Cell type atlas - PDE4D - The Human Protein Atlas

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PDE4D

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PDE4D
Gene descriptionⁱ Full gene name according to HGNC.	Phosphodiesterase 4D
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	16

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Alveolar cells type 2)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A549, AN3-CA, HeLa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Alveolar cells type 2)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	77 NX
Lung	77 NX

B-cells	9 NX
Colon	21 NX
Kidney	13 NX
Liver	2 NX

Basal glandular cells	31 NX
Prostate	31 NX

Basal keratinocytes	9 NX
Skin	9 NX

Bipolar cells	14 NX
Eye	14 NX

Cardiomyocytes	33 NX
Heart muscle	33 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	23 NX
Lung	23 NX

Club cells	49 NX
Lung	49 NX

Collecting duct cells	40 NX
Kidney	40 NX

Cone photoreceptor cells	69 NX
Eye	69 NX

Cytotrophoblasts	9 NX
Placenta	9 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	1 NX
Pancreas	1 NX

Early spermatids	17 NX
Testis	17 NX

Endothelial cells	12 NX
Eye	27 NX
Placenta	22 NX
Skin	21 NX
Heart muscle	18 NX
Prostate	11 NX
Liver	11 NX
Lung	6 NX
Pancreas	4 NX
Testis	2 NX

Enterocytes	17 NX
Rectum	32 NX
Colon	19 NX
Small intestine	8 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	2 NX
Pancreas	2 NX

Extravillous trophoblasts	15 NX
Placenta	15 NX

Fibroblasts	13 NX
Heart muscle	70 NX
Prostate	53 NX
Skin	16 NX
Lung	15 NX
Placenta	8 NX

Glandular cells	46 NX
Prostate	46 NX

Granulocytes	22 NX
Colon	28 NX
Lung	16 NX

Hepatocytes	1 NX
Liver	1 NX

Hofbauer cells	4 NX
Placenta	4 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	32 NX
Colon	48 NX
Rectum	16 NX

Ito cells	14 NX
Liver	14 NX

Kupffer cells	6 NX
Liver	6 NX

Late spermatids	29 NX
Testis	29 NX

Leydig cells	1 NX
Testis	1 NX

Macrophages	9 NX
Lung	29 NX
Prostate	19 NX
Kidney	16 NX
Skin	9 NX
Pancreas	7 NX
Testis	1 NX

Melanocytes	10 NX
Skin	10 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	5 NX
Pancreas	5 NX

Mucus-secreting cells	18 NX
Rectum	21 NX
Colon	16 NX
Small intestine	15 NX

Muller glia cells	16 NX
Eye	16 NX

Pancreatic endocrine cells	5 NX
Pancreas	5 NX

Paneth cells	11 NX
Rectum	13 NX
Small intestine	11 NX
Colon	9 NX

Peritubular cells	5 NX
Testis	5 NX

Proximal tubular cells	18 NX
Kidney	18 NX

Rod photoreceptor cells	52 NX
Eye	52 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	5 NX
Prostate	13 NX
Skin	8 NX
Heart muscle	5 NX
Pancreas	4 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	7 NX
Testis	7 NX

Suprabasal keratinocytes	8 NX
Skin	8 NX

Syncytiotrophoblasts	3 NX
Placenta	3 NX

T-cells	37 NX
Colon	221 NX
Lung	63 NX
Skin	52 NX
Prostate	48 NX
Kidney	15 NX
Liver	12 NX

Undifferentiated cells	10 NX
Rectum	12 NX
Colon	12 NX
Small intestine	6 NX

Urothelial cells	21 NX
Prostate	21 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.