Cell type atlas - CLK4 - The Human Protein Atlas

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CLK4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CLK4
Gene descriptionⁱ Full gene name according to HGNC.	CDC like kinase 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	27 NX
Lung	27 NX

B-cells	50 NX
Colon	88 NX
Kidney	58 NX
Liver	23 NX

Basal glandular cells	37 NX
Prostate	37 NX

Basal keratinocytes	28 NX
Skin	28 NX

Bipolar cells	66 NX
Eye	66 NX

Cardiomyocytes	19 NX
Heart muscle	19 NX

Cholangiocytes	8 NX
Liver	8 NX

Ciliated cells	32 NX
Lung	32 NX

Club cells	24 NX
Lung	24 NX

Collecting duct cells	14 NX
Kidney	14 NX

Cone photoreceptor cells	37 NX
Eye	37 NX

Cytotrophoblasts	17 NX
Placenta	16 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	7 NX
Pancreas	7 NX

Early spermatids	288 NX
Testis	288 NX

Endothelial cells	25 NX
Heart muscle	43 NX
Prostate	33 NX
Skin	25 NX
Testis	25 NX
Pancreas	25 NX
Placenta	24 NX
Lung	15 NX
Eye	14 NX
Liver	9 NX

Enterocytes	14 NX
Small intestine	16 NX
Colon	12 NX
Rectum	9 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	4 NX
Pancreas	4 NX

Extravillous trophoblasts	13 NX
Placenta	13 NX

Fibroblasts	21 NX
Prostate	42 NX
Heart muscle	39 NX
Skin	24 NX
Placenta	17 NX
Lung	14 NX

Glandular cells	26 NX
Prostate	26 NX

Granulocytes	28 NX
Colon	37 NX
Lung	19 NX

Hepatocytes	12 NX
Liver	12 NX

Hofbauer cells	9 NX
Placenta	9 NX

Horizontal cells	27 NX
Eye	27 NX

Intestinal endocrine cells	6 NX
Colon	7 NX
Rectum	5 NX

Ito cells	17 NX
Liver	17 NX

Kupffer cells	13 NX
Liver	13 NX

Late spermatids	351 NX
Testis	351 NX

Leydig cells	28 NX
Testis	28 NX

Macrophages	24 NX
Prostate	29 NX
Testis	26 NX
Skin	25 NX
Lung	21 NX
Kidney	21 NX
Pancreas	5 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	13 NX
Pancreas	13 NX

Mucus-secreting cells	11 NX
Rectum	14 NX
Small intestine	11 NX
Colon	6 NX

Muller glia cells	35 NX
Eye	35 NX

Pancreatic endocrine cells	7 NX
Pancreas	7 NX

Paneth cells	12 NX
Small intestine	28 NX
Rectum	12 NX
Colon	6 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	8 NX
Kidney	8 NX

Rod photoreceptor cells	76 NX
Eye	76 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	36 NX
Prostate	39 NX
Skin	37 NX
Heart muscle	28 NX
Pancreas	8 NX

Spermatocytes	23 NX
Testis	23 NX

Spermatogonia	18 NX
Testis	18 NX

Suprabasal keratinocytes	22 NX
Skin	22 NX

Syncytiotrophoblasts	13 NX
Placenta	13 NX

T-cells	35 NX
Colon	62 NX
Lung	55 NX
Prostate	35 NX
Skin	35 NX
Liver	29 NX
Kidney	29 NX

Undifferentiated cells	9 NX
Small intestine	10 NX
Rectum	9 NX
Colon	9 NX

Urothelial cells	22 NX
Prostate	22 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.