Cell type atlas - PRPF4B - The Human Protein Atlas

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PRPF4B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRPF4B
Gene descriptionⁱ Full gene name according to HGNC.	Pre-mRNA processing factor 4B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	101 NX
Lung	101 NX

Alveolar cells type 2	92 NX
Lung	92 NX

B-cells	89 NX
Colon	102 NX
Liver	101 NX
Kidney	58 NX

Basal glandular cells	54 NX
Prostate	54 NX

Basal keratinocytes	74 NX
Skin	74 NX

Bipolar cells	82 NX
Eye	82 NX

Cardiomyocytes	69 NX
Heart muscle	69 NX

Cholangiocytes	61 NX
Liver	61 NX

Ciliated cells	90 NX
Lung	90 NX

Club cells	101 NX
Lung	101 NX

Collecting duct cells	93 NX
Kidney	93 NX

Cone photoreceptor cells	84 NX
Eye	84 NX

Cytotrophoblasts	51 NX
Placenta	51 NX

Distal tubular cells	61 NX
Kidney	61 NX

Ductal cells	57 NX
Pancreas	57 NX

Early spermatids	9 NX
Testis	9 NX

Endothelial cells	82 NX
Heart muscle	127 NX
Lung	123 NX
Testis	93 NX
Eye	83 NX
Pancreas	82 NX
Liver	81 NX
Prostate	67 NX
Skin	40 NX
Placenta	40 NX

Enterocytes	58 NX
Colon	100 NX
Small intestine	48 NX
Rectum	44 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	50 NX
Pancreas	50 NX

Extravillous trophoblasts	41 NX
Placenta	41 NX

Fibroblasts	50 NX
Lung	131 NX
Heart muscle	93 NX
Prostate	62 NX
Skin	51 NX
Placenta	46 NX

Glandular cells	54 NX
Prostate	54 NX

Granulocytes	87 NX
Lung	109 NX
Colon	64 NX

Hepatocytes	77 NX
Liver	77 NX

Hofbauer cells	36 NX
Placenta	36 NX

Horizontal cells	100 NX
Eye	100 NX

Intestinal endocrine cells	72 NX
Colon	88 NX
Rectum	56 NX

Ito cells	68 NX
Liver	68 NX

Kupffer cells	59 NX
Liver	59 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	92 NX
Testis	92 NX

Macrophages	58 NX
Lung	127 NX
Kidney	69 NX
Testis	69 NX
Pancreas	47 NX
Skin	45 NX
Prostate	33 NX

Melanocytes	34 NX
Skin	34 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	71 NX
Pancreas	71 NX

Mucus-secreting cells	58 NX
Colon	123 NX
Small intestine	63 NX
Rectum	48 NX

Muller glia cells	81 NX
Eye	81 NX

Pancreatic endocrine cells	53 NX
Pancreas	52 NX

Paneth cells	58 NX
Small intestine	60 NX
Colon	58 NX
Rectum	50 NX

Peritubular cells	84 NX
Testis	84 NX

Proximal tubular cells	50 NX
Kidney	50 NX

Rod photoreceptor cells	181 NX
Eye	181 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	44 NX
Heart muscle	174 NX
Prostate	63 NX
Pancreas	44 NX
Skin	42 NX

Spermatocytes	68 NX
Testis	68 NX

Spermatogonia	79 NX
Testis	79 NX

Suprabasal keratinocytes	80 NX
Skin	80 NX

Syncytiotrophoblasts	53 NX
Placenta	53 NX

T-cells	69 NX
Lung	131 NX
Colon	117 NX
Liver	77 NX
Kidney	60 NX
Skin	53 NX
Prostate	35 NX

Undifferentiated cells	58 NX
Colon	115 NX
Small intestine	62 NX
Rectum	49 NX

Urothelial cells	64 NX
Prostate	64 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.