Cell type atlas - MCM3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MCM3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MCM3
Gene descriptionⁱ Full gene name according to HGNC.	Minichromosome maintenance complex component 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cytotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	11 NX
Lung	11 NX

B-cells	31 NX
Kidney	36 NX
Colon	25 NX
Liver	24 NX

Basal glandular cells	14 NX
Prostate	14 NX

Basal keratinocytes	17 NX
Skin	17 NX

Bipolar cells	14 NX
Eye	14 NX

Cardiomyocytes	14 NX
Heart muscle	14 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	23 NX
Lung	23 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	85 NX
Placenta	85 NX

Distal tubular cells	12 NX
Kidney	12 NX

Ductal cells	21 NX
Pancreas	21 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	25 NX
Pancreas	57 NX
Placenta	34 NX
Testis	29 NX
Lung	29 NX
Eye	25 NX
Prostate	23 NX
Liver	18 NX
Skin	18 NX
Heart muscle	17 NX

Enterocytes	5 NX
Small intestine	6 NX
Colon	4 NX
Rectum	4 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	18 NX
Pancreas	18 NX

Extravillous trophoblasts	53 NX
Placenta	53 NX

Fibroblasts	16 NX
Placenta	38 NX
Lung	20 NX
Heart muscle	16 NX
Skin	10 NX
Prostate	6 NX

Glandular cells	8 NX
Prostate	8 NX

Granulocytes	37 NX
Colon	46 NX
Lung	28 NX

Hepatocytes	9 NX
Liver	9 NX

Hofbauer cells	31 NX
Placenta	31 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	7 NX
Rectum	14 NX
Colon	0 NX

Ito cells	15 NX
Liver	15 NX

Kupffer cells	9 NX
Liver	9 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	25 NX
Testis	25 NX

Macrophages	14 NX
Lung	17 NX
Pancreas	16 NX
Testis	15 NX
Kidney	14 NX
Skin	10 NX
Prostate	2 NX

Melanocytes	7 NX
Skin	7 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	11 NX
Pancreas	11 NX

Mucus-secreting cells	17 NX
Small intestine	24 NX
Colon	16 NX
Rectum	10 NX

Muller glia cells	19 NX
Eye	19 NX

Pancreatic endocrine cells	13 NX
Pancreas	13 NX

Paneth cells	11 NX
Rectum	18 NX
Small intestine	11 NX
Colon	0 NX

Peritubular cells	20 NX
Testis	20 NX

Proximal tubular cells	7 NX
Kidney	7 NX

Rod photoreceptor cells	11 NX
Eye	11 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	25 NX
Heart muscle	40 NX
Pancreas	33 NX
Skin	20 NX
Prostate	10 NX

Spermatocytes	22 NX
Testis	22 NX

Spermatogonia	59 NX
Testis	59 NX

Suprabasal keratinocytes	9 NX
Skin	9 NX

Syncytiotrophoblasts	23 NX
Placenta	23 NX

T-cells	28 NX
Kidney	40 NX
Liver	34 NX
Lung	29 NX
Colon	24 NX
Skin	14 NX
Prostate	4 NX

Undifferentiated cells	31 NX
Small intestine	47 NX
Colon	37 NX
Rectum	18 NX

Urothelial cells	11 NX
Prostate	11 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.