Cell type atlas - TDP2 - The Human Protein Atlas

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TDP2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TDP2
Gene descriptionⁱ Full gene name according to HGNC.	Tyrosyl-DNA phosphodiesterase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Enterocytes, Paneth cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (neutrophil, basophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Enterocytes, Paneth cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	15 NX
Lung	15 NX

B-cells	22 NX
Colon	31 NX
Kidney	22 NX
Liver	11 NX

Basal glandular cells	25 NX
Prostate	25 NX

Basal keratinocytes	13 NX
Skin	13 NX

Bipolar cells	11 NX
Eye	11 NX

Cardiomyocytes	16 NX
Heart muscle	16 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	27 NX
Lung	27 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	16 NX
Placenta	16 NX

Distal tubular cells	41 NX
Kidney	41 NX

Ductal cells	30 NX
Pancreas	30 NX

Early spermatids	142 NX
Testis	142 NX

Endothelial cells	21 NX
Pancreas	29 NX
Liver	27 NX
Heart muscle	27 NX
Skin	25 NX
Testis	21 NX
Lung	20 NX
Prostate	18 NX
Placenta	16 NX
Eye	8 NX

Enterocytes	435 NX
Rectum	546 NX
Small intestine	522 NX
Colon	234 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	31 NX
Pancreas	31 NX

Extravillous trophoblasts	21 NX
Placenta	21 NX

Fibroblasts	17 NX
Prostate	26 NX
Skin	19 NX
Placenta	14 NX
Heart muscle	12 NX
Lung	9 NX

Glandular cells	29 NX
Prostate	29 NX

Granulocytes	23 NX
Lung	28 NX
Colon	18 NX

Hepatocytes	27 NX
Liver	27 NX

Hofbauer cells	65 NX
Placenta	65 NX

Horizontal cells	6 NX
Eye	6 NX

Intestinal endocrine cells	51 NX
Colon	54 NX
Rectum	47 NX

Ito cells	23 NX
Liver	23 NX

Kupffer cells	23 NX
Liver	23 NX

Late spermatids	64 NX
Testis	64 NX

Leydig cells	17 NX
Testis	17 NX

Macrophages	29 NX
Pancreas	117 NX
Prostate	34 NX
Kidney	33 NX
Lung	32 NX
Testis	24 NX
Skin	19 NX

Melanocytes	12 NX
Skin	12 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	85 NX
Pancreas	85 NX

Mucus-secreting cells	117 NX
Small intestine	188 NX
Colon	144 NX
Rectum	91 NX

Muller glia cells	17 NX
Eye	17 NX

Pancreatic endocrine cells	20 NX
Pancreas	20 NX

Paneth cells	431 NX
Colon	438 NX
Small intestine	431 NX
Rectum	291 NX

Peritubular cells	22 NX
Testis	22 NX

Proximal tubular cells	159 NX
Kidney	159 NX

Rod photoreceptor cells	14 NX
Eye	14 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	21 NX
Pancreas	31 NX
Skin	23 NX
Prostate	20 NX
Heart muscle	17 NX

Spermatocytes	9 NX
Testis	9 NX

Spermatogonia	20 NX
Testis	20 NX

Suprabasal keratinocytes	14 NX
Skin	14 NX

Syncytiotrophoblasts	37 NX
Placenta	37 NX

T-cells	28 NX
Kidney	47 NX
Colon	39 NX
Liver	31 NX
Lung	25 NX
Skin	23 NX
Prostate	9 NX

Undifferentiated cells	86 NX
Colon	110 NX
Rectum	86 NX
Small intestine	73 NX

Urothelial cells	22 NX
Prostate	22 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.