Cell type atlas - CHD4 - The Human Protein Atlas

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CHD4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CHD4
Gene descriptionⁱ Full gene name according to HGNC.	Chromodomain helicase DNA binding protein 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	22

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	57 NX
Lung	57 NX

Alveolar cells type 2	102 NX
Lung	102 NX

B-cells	59 NX
Colon	76 NX
Liver	62 NX
Kidney	22 NX

Basal glandular cells	46 NX
Prostate	46 NX

Basal keratinocytes	61 NX
Skin	61 NX

Bipolar cells	103 NX
Eye	103 NX

Cardiomyocytes	111 NX
Heart muscle	111 NX

Cholangiocytes	66 NX
Liver	66 NX

Ciliated cells	96 NX
Lung	96 NX

Club cells	80 NX
Lung	80 NX

Collecting duct cells	84 NX
Kidney	84 NX

Cone photoreceptor cells	67 NX
Eye	67 NX

Cytotrophoblasts	39 NX
Placenta	39 NX

Distal tubular cells	12 NX
Kidney	12 NX

Ductal cells	71 NX
Pancreas	71 NX

Early spermatids	72 NX
Testis	72 NX

Endothelial cells	71 NX
Liver	79 NX
Eye	77 NX
Lung	73 NX
Placenta	72 NX
Prostate	71 NX
Heart muscle	71 NX
Testis	70 NX
Skin	63 NX
Pancreas	57 NX

Enterocytes	43 NX
Colon	45 NX
Rectum	44 NX
Small intestine	39 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	62 NX
Pancreas	62 NX

Extravillous trophoblasts	42 NX
Placenta	42 NX

Fibroblasts	67 NX
Lung	123 NX
Heart muscle	69 NX
Placenta	68 NX
Skin	63 NX
Prostate	58 NX

Glandular cells	40 NX
Prostate	40 NX

Granulocytes	81 NX
Lung	126 NX
Colon	37 NX

Hepatocytes	61 NX
Liver	61 NX

Hofbauer cells	61 NX
Placenta	61 NX

Horizontal cells	132 NX
Eye	132 NX

Intestinal endocrine cells	93 NX
Colon	95 NX
Rectum	91 NX

Ito cells	50 NX
Liver	50 NX

Kupffer cells	44 NX
Liver	44 NX

Late spermatids	45 NX
Testis	45 NX

Leydig cells	61 NX
Testis	61 NX

Macrophages	58 NX
Testis	66 NX
Lung	65 NX
Skin	63 NX
Prostate	54 NX
Kidney	47 NX
Pancreas	37 NX

Melanocytes	46 NX
Skin	46 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	57 NX
Pancreas	57 NX

Mucus-secreting cells	59 NX
Colon	68 NX
Rectum	59 NX
Small intestine	45 NX

Muller glia cells	72 NX
Eye	72 NX

Pancreatic endocrine cells	77 NX
Pancreas	77 NX

Paneth cells	25 NX
Rectum	57 NX
Small intestine	25 NX
Colon	17 NX

Peritubular cells	70 NX
Testis	70 NX

Proximal tubular cells	30 NX
Kidney	30 NX

Rod photoreceptor cells	60 NX
Eye	60 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	74 NX
Heart muscle	120 NX
Skin	75 NX
Pancreas	71 NX
Prostate	53 NX

Spermatocytes	97 NX
Testis	97 NX

Spermatogonia	107 NX
Testis	107 NX

Suprabasal keratinocytes	59 NX
Skin	59 NX

Syncytiotrophoblasts	57 NX
Placenta	57 NX

T-cells	62 NX
Skin	78 NX
Lung	76 NX
Colon	72 NX
Liver	56 NX
Kidney	42 NX
Prostate	13 NX

Undifferentiated cells	62 NX
Colon	69 NX
Rectum	62 NX
Small intestine	60 NX

Urothelial cells	37 NX
Prostate	37 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.