Cell type atlas - GAPDH - The Human Protein Atlas

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GAPDH

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GAPDH
Gene descriptionⁱ Full gene name according to HGNC.	Glyceraldehyde-3-phosphate dehydrogenase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	220 NX
Lung	220 NX

Alveolar cells type 2	245 NX
Lung	245 NX

B-cells	821 NX
Liver	2483 NX
Colon	733 NX
Kidney	722 NX

Basal glandular cells	1485 NX
Prostate	1485 NX

Basal keratinocytes	1616 NX
Skin	1616 NX

Bipolar cells	992 NX
Eye	992 NX

Cardiomyocytes	33 NX
Heart muscle	33 NX

Cholangiocytes	1355 NX
Liver	1355 NX

Ciliated cells	276 NX
Lung	276 NX

Club cells	445 NX
Lung	445 NX

Collecting duct cells	970 NX
Kidney	970 NX

Cone photoreceptor cells	393 NX
Eye	393 NX

Cytotrophoblasts	4082 NX
Placenta	4082 NX

Distal tubular cells	2935 NX
Kidney	2935 NX

Ductal cells	4447 NX
Pancreas	4447 NX

Early spermatids	584 NX
Testis	584 NX

Endothelial cells	1564 NX
Prostate	3039 NX
Placenta	2481 NX
Pancreas	2324 NX
Skin	1767 NX
Liver	1564 NX
Eye	1548 NX
Testis	1238 NX
Lung	519 NX
Heart muscle	9 NX

Enterocytes	2837 NX
Small intestine	4582 NX
Rectum	2612 NX
Colon	1949 NX

Erythroid cells	444 NX
Liver	444 NX

Exocrine glandular cells	3300 NX
Pancreas	3299 NX

Extravillous trophoblasts	7141 NX
Placenta	7141 NX

Fibroblasts	1485 NX
Placenta	2003 NX
Prostate	1485 NX
Skin	1313 NX
Lung	598 NX
Heart muscle	14 NX

Glandular cells	1124 NX
Prostate	1124 NX

Granulocytes	552 NX
Colon	634 NX
Lung	470 NX

Hepatocytes	1346 NX
Liver	1346 NX

Hofbauer cells	3471 NX
Placenta	3471 NX

Horizontal cells	2218 NX
Eye	2218 NX

Intestinal endocrine cells	1273 NX
Rectum	1592 NX
Colon	955 NX

Ito cells	1144 NX
Liver	1144 NX

Kupffer cells	2600 NX
Liver	2600 NX

Late spermatids	1557 NX
Testis	1557 NX

Leydig cells	824 NX
Testis	824 NX

Macrophages	2367 NX
Pancreas	4569 NX
Prostate	3037 NX
Testis	2487 NX
Kidney	2398 NX
Skin	1907 NX
Lung	727 NX

Melanocytes	4004 NX
Skin	4004 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	3613 NX
Pancreas	3613 NX

Mucus-secreting cells	2061 NX
Rectum	2205 NX
Small intestine	2089 NX
Colon	1917 NX

Muller glia cells	5235 NX
Eye	5235 NX

Pancreatic endocrine cells	4743 NX
Pancreas	4743 NX

Paneth cells	2688 NX
Small intestine	2816 NX
Rectum	2688 NX
Colon	2640 NX

Peritubular cells	965 NX
Testis	965 NX

Proximal tubular cells	5345 NX
Kidney	5345 NX

Rod photoreceptor cells	1026 NX
Eye	1026 NX

Sertoli cells	1132 NX
Testis	1132 NX

Smooth muscle cells	2133 NX
Pancreas	7678 NX
Prostate	3014 NX
Skin	1963 NX
Heart muscle	24 NX

Spermatocytes	430 NX
Testis	430 NX

Spermatogonia	391 NX
Testis	391 NX

Suprabasal keratinocytes	1399 NX
Skin	1399 NX

Syncytiotrophoblasts	3926 NX
Placenta	3926 NX

T-cells	1271 NX
Skin	2765 NX
Liver	1454 NX
Kidney	1414 NX
Prostate	1133 NX
Colon	980 NX
Lung	564 NX

Undifferentiated cells	3010 NX
Small intestine	3830 NX
Rectum	3010 NX
Colon	1649 NX

Urothelial cells	2464 NX
Prostate	2464 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.