Cell type atlas - METAP2 - The Human Protein Atlas

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METAP2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	METAP2
Gene descriptionⁱ Full gene name according to HGNC.	Methionyl aminopeptidase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	262 NX
Lung	262 NX

Alveolar cells type 2	229 NX
Lung	229 NX

B-cells	97 NX
Liver	169 NX
Colon	96 NX
Kidney	54 NX

Basal glandular cells	103 NX
Prostate	103 NX

Basal keratinocytes	207 NX
Skin	207 NX

Bipolar cells	63 NX
Eye	63 NX

Cardiomyocytes	117 NX
Heart muscle	117 NX

Cholangiocytes	92 NX
Liver	92 NX

Ciliated cells	104 NX
Lung	104 NX

Club cells	160 NX
Lung	160 NX

Collecting duct cells	276 NX
Kidney	276 NX

Cone photoreceptor cells	63 NX
Eye	63 NX

Cytotrophoblasts	126 NX
Placenta	126 NX

Distal tubular cells	139 NX
Kidney	139 NX

Ductal cells	95 NX
Pancreas	95 NX

Early spermatids	136 NX
Testis	136 NX

Endothelial cells	105 NX
Pancreas	150 NX
Liver	135 NX
Lung	131 NX
Testis	121 NX
Skin	101 NX
Heart muscle	95 NX
Prostate	91 NX
Placenta	89 NX
Eye	65 NX

Enterocytes	80 NX
Colon	105 NX
Small intestine	81 NX
Rectum	44 NX

Erythroid cells	257 NX
Liver	257 NX

Exocrine glandular cells	126 NX
Pancreas	126 NX

Extravillous trophoblasts	136 NX
Placenta	136 NX

Fibroblasts	103 NX
Lung	230 NX
Heart muscle	116 NX
Skin	103 NX
Placenta	101 NX
Prostate	86 NX

Glandular cells	69 NX
Prostate	69 NX

Granulocytes	119 NX
Lung	128 NX
Colon	110 NX

Hepatocytes	279 NX
Liver	279 NX

Hofbauer cells	87 NX
Placenta	87 NX

Horizontal cells	72 NX
Eye	72 NX

Intestinal endocrine cells	88 NX
Colon	92 NX
Rectum	84 NX

Ito cells	103 NX
Liver	103 NX

Kupffer cells	122 NX
Liver	122 NX

Late spermatids	83 NX
Testis	83 NX

Leydig cells	93 NX
Testis	93 NX

Macrophages	93 NX
Lung	121 NX
Testis	105 NX
Kidney	100 NX
Pancreas	87 NX
Skin	75 NX
Prostate	64 NX

Melanocytes	88 NX
Skin	88 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	80 NX
Pancreas	80 NX

Mucus-secreting cells	110 NX
Colon	126 NX
Rectum	111 NX
Small intestine	86 NX

Muller glia cells	68 NX
Eye	68 NX

Pancreatic endocrine cells	106 NX
Pancreas	106 NX

Paneth cells	83 NX
Rectum	126 NX
Colon	83 NX
Small intestine	77 NX

Peritubular cells	100 NX
Testis	100 NX

Proximal tubular cells	82 NX
Kidney	82 NX

Rod photoreceptor cells	69 NX
Eye	69 NX

Sertoli cells	97 NX
Testis	97 NX

Smooth muscle cells	98 NX
Pancreas	118 NX
Prostate	105 NX
Skin	92 NX
Heart muscle	82 NX

Spermatocytes	341 NX
Testis	341 NX

Spermatogonia	217 NX
Testis	217 NX

Suprabasal keratinocytes	188 NX
Skin	188 NX

Syncytiotrophoblasts	144 NX
Placenta	144 NX

T-cells	94 NX
Liver	98 NX
Lung	95 NX
Colon	94 NX
Kidney	68 NX
Skin	63 NX
Prostate	52 NX

Undifferentiated cells	119 NX
Colon	160 NX
Small intestine	119 NX
Rectum	102 NX

Urothelial cells	91 NX
Prostate	91 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.