Cell type atlas - AIP - The Human Protein Atlas

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AIP

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AIP
Gene descriptionⁱ Full gene name according to HGNC.	Aryl hydrocarbon receptor interacting protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	25 NX
Lung	25 NX

B-cells	51 NX
Liver	81 NX
Colon	51 NX
Kidney	49 NX

Basal glandular cells	30 NX
Prostate	30 NX

Basal keratinocytes	27 NX
Skin	27 NX

Bipolar cells	32 NX
Eye	32 NX

Cardiomyocytes	19 NX
Heart muscle	19 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	13 NX
Lung	13 NX

Club cells	15 NX
Lung	15 NX

Collecting duct cells	47 NX
Kidney	47 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	49 NX
Placenta	49 NX

Distal tubular cells	70 NX
Kidney	70 NX

Ductal cells	41 NX
Pancreas	41 NX

Early spermatids	21 NX
Testis	21 NX

Endothelial cells	48 NX
Testis	64 NX
Placenta	63 NX
Prostate	63 NX
Pancreas	61 NX
Liver	59 NX
Eye	45 NX
Skin	42 NX
Lung	35 NX
Heart muscle	23 NX

Enterocytes	50 NX
Small intestine	60 NX
Colon	50 NX
Rectum	31 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	37 NX
Pancreas	37 NX

Extravillous trophoblasts	48 NX
Placenta	48 NX

Fibroblasts	45 NX
Placenta	59 NX
Prostate	52 NX
Skin	43 NX
Heart muscle	23 NX
Lung	13 NX

Glandular cells	36 NX
Prostate	36 NX

Granulocytes	75 NX
Lung	77 NX
Colon	74 NX

Hepatocytes	22 NX
Liver	22 NX

Hofbauer cells	60 NX
Placenta	60 NX

Horizontal cells	35 NX
Eye	35 NX

Intestinal endocrine cells	31 NX
Rectum	37 NX
Colon	24 NX

Ito cells	41 NX
Liver	41 NX

Kupffer cells	53 NX
Liver	53 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	49 NX
Testis	49 NX

Macrophages	58 NX
Kidney	75 NX
Testis	72 NX
Pancreas	59 NX
Prostate	58 NX
Skin	55 NX
Lung	41 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	72 NX
Pancreas	72 NX

Mucus-secreting cells	27 NX
Small intestine	39 NX
Colon	34 NX
Rectum	21 NX

Muller glia cells	35 NX
Eye	35 NX

Pancreatic endocrine cells	41 NX
Pancreas	41 NX

Paneth cells	49 NX
Colon	69 NX
Small intestine	49 NX
Rectum	26 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	68 NX
Kidney	68 NX

Rod photoreceptor cells	25 NX
Eye	25 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	54 NX
Prostate	73 NX
Heart muscle	61 NX
Skin	50 NX
Pancreas	49 NX

Spermatocytes	25 NX
Testis	25 NX

Spermatogonia	29 NX
Testis	29 NX

Suprabasal keratinocytes	18 NX
Skin	18 NX

Syncytiotrophoblasts	50 NX
Placenta	50 NX

T-cells	95 NX
Kidney	115 NX
Liver	105 NX
Skin	95 NX
Colon	79 NX
Prostate	61 NX
Lung	59 NX

Undifferentiated cells	22 NX
Small intestine	24 NX
Colon	21 NX
Rectum	20 NX

Urothelial cells	36 NX
Prostate	36 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.