Cell type atlas - HIPK3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

HIPK3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HIPK3
Gene descriptionⁱ Full gene name according to HGNC.	Homeodomain interacting protein kinase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	12 NX
Lung	12 NX

Alveolar cells type 2	40 NX
Lung	40 NX

B-cells	20 NX
Kidney	22 NX
Colon	21 NX
Liver	16 NX

Basal glandular cells	38 NX
Prostate	38 NX

Basal keratinocytes	59 NX
Skin	59 NX

Bipolar cells	15 NX
Eye	15 NX

Cardiomyocytes	138 NX
Heart muscle	138 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	60 NX
Lung	60 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	31 NX
Kidney	31 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	15 NX
Placenta	15 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	11 NX
Pancreas	11 NX

Early spermatids	17 NX
Testis	17 NX

Endothelial cells	81 NX
Skin	170 NX
Prostate	122 NX
Heart muscle	98 NX
Testis	81 NX
Lung	73 NX
Eye	47 NX
Liver	43 NX
Placenta	22 NX
Pancreas	18 NX

Enterocytes	35 NX
Colon	38 NX
Small intestine	36 NX
Rectum	28 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	21 NX
Pancreas	21 NX

Extravillous trophoblasts	11 NX
Placenta	11 NX

Fibroblasts	37 NX
Heart muscle	95 NX
Skin	70 NX
Lung	56 NX
Prostate	37 NX
Placenta	24 NX

Glandular cells	35 NX
Prostate	35 NX

Granulocytes	14 NX
Lung	19 NX
Colon	9 NX

Hepatocytes	45 NX
Liver	45 NX

Hofbauer cells	27 NX
Placenta	27 NX

Horizontal cells	30 NX
Eye	30 NX

Intestinal endocrine cells	36 NX
Colon	41 NX
Rectum	31 NX

Ito cells	50 NX
Liver	50 NX

Kupffer cells	101 NX
Liver	101 NX

Late spermatids	22 NX
Testis	22 NX

Leydig cells	40 NX
Testis	40 NX

Macrophages	52 NX
Testis	64 NX
Skin	56 NX
Prostate	53 NX
Kidney	52 NX
Lung	45 NX
Pancreas	21 NX

Melanocytes	56 NX
Skin	56 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	6 NX
Pancreas	6 NX

Mucus-secreting cells	27 NX
Rectum	31 NX
Colon	23 NX
Small intestine	19 NX

Muller glia cells	11 NX
Eye	11 NX

Pancreatic endocrine cells	19 NX
Pancreas	19 NX

Paneth cells	22 NX
Small intestine	25 NX
Rectum	22 NX
Colon	12 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	28 NX
Kidney	28 NX

Rod photoreceptor cells	24 NX
Eye	24 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	63 NX
Skin	73 NX
Heart muscle	63 NX
Prostate	58 NX
Pancreas	8 NX

Spermatocytes	10 NX
Testis	10 NX

Spermatogonia	8 NX
Testis	8 NX

Suprabasal keratinocytes	66 NX
Skin	66 NX

Syncytiotrophoblasts	13 NX
Placenta	13 NX

T-cells	17 NX
Skin	30 NX
Colon	26 NX
Prostate	22 NX
Lung	17 NX
Liver	14 NX
Kidney	13 NX

Undifferentiated cells	20 NX
Rectum	23 NX
Colon	20 NX
Small intestine	19 NX

Urothelial cells	43 NX
Prostate	43 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.