Cell type atlas - HSPA8 - The Human Protein Atlas

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HSPA8

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HSPA8
Gene descriptionⁱ Full gene name according to HGNC.	Heat shock protein family A (Hsp70) member 8
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	17

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	179 NX
Lung	179 NX

Alveolar cells type 2	194 NX
Lung	194 NX

B-cells	381 NX
Colon	449 NX
Liver	393 NX
Kidney	312 NX

Basal glandular cells	2008 NX
Prostate	2008 NX

Basal keratinocytes	251 NX
Skin	251 NX

Bipolar cells	193 NX
Eye	193 NX

Cardiomyocytes	358 NX
Heart muscle	358 NX

Cholangiocytes	247 NX
Liver	247 NX

Ciliated cells	398 NX
Lung	398 NX

Club cells	239 NX
Lung	239 NX

Collecting duct cells	124 NX
Kidney	124 NX

Cone photoreceptor cells	120 NX
Eye	120 NX

Cytotrophoblasts	806 NX
Placenta	806 NX

Distal tubular cells	448 NX
Kidney	448 NX

Ductal cells	560 NX
Pancreas	560 NX

Early spermatids	24 NX
Testis	23 NX

Endothelial cells	384 NX
Prostate	997 NX
Pancreas	652 NX
Skin	591 NX
Placenta	439 NX
Eye	384 NX
Testis	306 NX
Liver	286 NX
Lung	193 NX
Heart muscle	164 NX

Enterocytes	634 NX
Small intestine	695 NX
Colon	634 NX
Rectum	248 NX

Erythroid cells	257 NX
Liver	257 NX

Exocrine glandular cells	544 NX
Pancreas	544 NX

Extravillous trophoblasts	849 NX
Placenta	849 NX

Fibroblasts	487 NX
Prostate	1354 NX
Lung	663 NX
Skin	501 NX
Placenta	387 NX
Heart muscle	182 NX

Glandular cells	804 NX
Prostate	804 NX

Granulocytes	432 NX
Colon	597 NX
Lung	267 NX

Hepatocytes	182 NX
Liver	182 NX

Hofbauer cells	716 NX
Placenta	716 NX

Horizontal cells	172 NX
Eye	172 NX

Intestinal endocrine cells	498 NX
Colon	765 NX
Rectum	232 NX

Ito cells	193 NX
Liver	193 NX

Kupffer cells	238 NX
Liver	238 NX

Late spermatids	51 NX
Testis	51 NX

Leydig cells	206 NX
Testis	206 NX

Macrophages	454 NX
Prostate	1945 NX
Skin	825 NX
Pancreas	487 NX
Testis	395 NX
Lung	356 NX
Kidney	329 NX

Melanocytes	501 NX
Skin	501 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	662 NX
Pancreas	662 NX

Mucus-secreting cells	247 NX
Colon	810 NX
Small intestine	282 NX
Rectum	232 NX

Muller glia cells	285 NX
Eye	285 NX

Pancreatic endocrine cells	500 NX
Pancreas	500 NX

Paneth cells	403 NX
Colon	795 NX
Small intestine	403 NX
Rectum	286 NX

Peritubular cells	254 NX
Testis	254 NX

Proximal tubular cells	795 NX
Kidney	795 NX

Rod photoreceptor cells	190 NX
Eye	190 NX

Sertoli cells	239 NX
Testis	239 NX

Smooth muscle cells	547 NX
Prostate	1149 NX
Pancreas	807 NX
Skin	542 NX
Heart muscle	210 NX

Spermatocytes	181 NX
Testis	181 NX

Spermatogonia	437 NX
Testis	437 NX

Suprabasal keratinocytes	249 NX
Skin	249 NX

Syncytiotrophoblasts	1265 NX
Placenta	1265 NX

T-cells	601 NX
Prostate	4284 NX
Skin	1160 NX
Colon	633 NX
Kidney	601 NX
Liver	418 NX
Lung	309 NX

Undifferentiated cells	395 NX
Colon	726 NX
Small intestine	475 NX
Rectum	322 NX

Urothelial cells	698 NX
Prostate	698 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.