Cell type atlas - MTCH2 - The Human Protein Atlas

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MTCH2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MTCH2
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrial carrier 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Proximal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Proximal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	34 NX
Lung	34 NX

B-cells	37 NX
Liver	64 NX
Kidney	40 NX
Colon	34 NX

Basal glandular cells	43 NX
Prostate	43 NX

Basal keratinocytes	42 NX
Skin	42 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	61 NX
Heart muscle	61 NX

Cholangiocytes	82 NX
Liver	82 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	38 NX
Lung	38 NX

Collecting duct cells	51 NX
Kidney	51 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	76 NX
Placenta	76 NX

Distal tubular cells	154 NX
Kidney	154 NX

Ductal cells	137 NX
Pancreas	136 NX

Early spermatids	433 NX
Testis	433 NX

Endothelial cells	25 NX
Pancreas	65 NX
Placenta	49 NX
Prostate	30 NX
Skin	29 NX
Liver	27 NX
Testis	25 NX
Heart muscle	18 NX
Lung	9 NX
Eye	0 NX

Enterocytes	133 NX
Small intestine	165 NX
Rectum	103 NX
Colon	72 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	95 NX
Pancreas	95 NX

Extravillous trophoblasts	102 NX
Placenta	102 NX

Fibroblasts	32 NX
Placenta	81 NX
Heart muscle	47 NX
Prostate	30 NX
Skin	29 NX
Lung	21 NX

Glandular cells	65 NX
Prostate	65 NX

Granulocytes	36 NX
Lung	44 NX
Colon	28 NX

Hepatocytes	266 NX
Liver	266 NX

Hofbauer cells	146 NX
Placenta	146 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	77 NX
Rectum	82 NX
Colon	71 NX

Ito cells	35 NX
Liver	35 NX

Kupffer cells	64 NX
Liver	64 NX

Late spermatids	111 NX
Testis	111 NX

Leydig cells	27 NX
Testis	27 NX

Macrophages	51 NX
Pancreas	155 NX
Kidney	98 NX
Prostate	87 NX
Testis	62 NX
Skin	38 NX
Lung	36 NX

Melanocytes	78 NX
Skin	78 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	113 NX
Pancreas	113 NX

Mucus-secreting cells	83 NX
Colon	111 NX
Rectum	72 NX
Small intestine	64 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	85 NX
Pancreas	85 NX

Paneth cells	63 NX
Rectum	98 NX
Small intestine	63 NX
Colon	29 NX

Peritubular cells	55 NX
Testis	55 NX

Proximal tubular cells	399 NX
Kidney	399 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	38 NX
Pancreas	121 NX
Prostate	52 NX
Skin	37 NX
Heart muscle	29 NX

Spermatocytes	328 NX
Testis	328 NX

Spermatogonia	81 NX
Testis	81 NX

Suprabasal keratinocytes	47 NX
Skin	47 NX

Syncytiotrophoblasts	107 NX
Placenta	107 NX

T-cells	38 NX
Kidney	68 NX
Skin	38 NX
Colon	38 NX
Liver	36 NX
Lung	30 NX
Prostate	4 NX

Undifferentiated cells	135 NX
Colon	193 NX
Small intestine	168 NX
Rectum	127 NX

Urothelial cells	50 NX
Prostate	50 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.