Cell type atlas - AREG - The Human Protein Atlas

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AREG

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AREG
Gene descriptionⁱ Full gene name according to HGNC.	Amphiregulin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Basal keratinocytes, Basal glandular cells, granulocytes, Enterocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (eosinophil, basophil, NK-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (CACO-2, HBEC3-KT, hTCEpi, hTERT-HME1, MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Basal keratinocytes, Basal glandular cells, granulocytes, Enterocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	185 NX
Lung	185 NX

Alveolar cells type 2	339 NX
Lung	339 NX

B-cells	83 NX
Colon	203 NX
Liver	79 NX
Kidney	36 NX

Basal glandular cells	760 NX
Prostate	760 NX

Basal keratinocytes	994 NX
Skin	994 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	31 NX
Heart muscle	31 NX

Cholangiocytes	71 NX
Liver	71 NX

Ciliated cells	92 NX
Lung	92 NX

Club cells	311 NX
Lung	311 NX

Collecting duct cells	49 NX
Kidney	49 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	1 NX
Placenta	1 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	53 NX
Pancreas	53 NX

Early spermatids	45 NX
Testis	45 NX

Endothelial cells	4 NX
Prostate	78 NX
Eye	63 NX
Lung	55 NX
Skin	24 NX
Liver	7 NX
Pancreas	4 NX
Heart muscle	3 NX
Placenta	2 NX
Testis	1 NX

Enterocytes	632 NX
Colon	1058 NX
Rectum	468 NX
Small intestine	41 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	9 NX
Pancreas	9 NX

Extravillous trophoblasts	1 NX
Placenta	1 NX

Fibroblasts	28 NX
Lung	226 NX
Prostate	165 NX
Placenta	65 NX
Heart muscle	28 NX
Skin	3 NX

Glandular cells	74 NX
Prostate	74 NX

Granulocytes	634 NX
Lung	1139 NX
Colon	129 NX

Hepatocytes	3 NX
Liver	3 NX

Hofbauer cells	32 NX
Placenta	32 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	40 NX
Colon	68 NX
Rectum	12 NX

Ito cells	10 NX
Liver	10 NX

Kupffer cells	190 NX
Liver	190 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	0 NX
Testis	0 NX

Macrophages	134 NX
Prostate	2783 NX
Testis	1312 NX
Lung	821 NX
Skin	99 NX
Kidney	70 NX
Pancreas	0 NX

Melanocytes	32 NX
Skin	32 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	2 NX
Pancreas	2 NX

Mucus-secreting cells	188 NX
Colon	681 NX
Small intestine	294 NX
Rectum	78 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	302 NX
Pancreas	302 NX

Paneth cells	221 NX
Colon	2004 NX
Small intestine	221 NX
Rectum	181 NX

Peritubular cells	1 NX
Testis	1 NX

Proximal tubular cells	1 NX
Kidney	1 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	4 NX
Prostate	72 NX
Skin	6 NX
Heart muscle	4 NX
Pancreas	1 NX

Spermatocytes	52 NX
Testis	52 NX

Spermatogonia	45 NX
Testis	45 NX

Suprabasal keratinocytes	299 NX
Skin	299 NX

Syncytiotrophoblasts	1 NX
Placenta	1 NX

T-cells	150 NX
Prostate	3055 NX
Liver	183 NX
Lung	150 NX
Colon	132 NX
Kidney	42 NX
Skin	28 NX

Undifferentiated cells	120 NX
Colon	323 NX
Small intestine	105 NX
Rectum	85 NX

Urothelial cells	1408 NX
Prostate	1408 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.