Cell type atlas - NFKB1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NFKB1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NFKB1
Gene descriptionⁱ Full gene name according to HGNC.	Nuclear factor kappa B subunit 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes FDA approved drug targets Plasma proteins RAS pathway related proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	47 NX
Lung	47 NX

B-cells	27 NX
Colon	146 NX
Kidney	27 NX
Liver	25 NX

Basal glandular cells	82 NX
Prostate	82 NX

Basal keratinocytes	147 NX
Skin	147 NX

Bipolar cells	7 NX
Eye	7 NX

Cardiomyocytes	17 NX
Heart muscle	17 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	36 NX
Lung	36 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	13 NX
Placenta	13 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	26 NX
Pancreas	26 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	31 NX
Skin	95 NX
Prostate	90 NX
Lung	55 NX
Pancreas	32 NX
Eye	31 NX
Liver	29 NX
Heart muscle	25 NX
Placenta	23 NX
Testis	19 NX

Enterocytes	32 NX
Rectum	40 NX
Colon	36 NX
Small intestine	19 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	32 NX
Pancreas	32 NX

Extravillous trophoblasts	14 NX
Placenta	14 NX

Fibroblasts	46 NX
Skin	172 NX
Prostate	142 NX
Lung	46 NX
Heart muscle	35 NX
Placenta	19 NX

Glandular cells	57 NX
Prostate	57 NX

Granulocytes	112 NX
Colon	175 NX
Lung	49 NX

Hepatocytes	20 NX
Liver	20 NX

Hofbauer cells	23 NX
Placenta	23 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	32 NX
Colon	34 NX
Rectum	31 NX

Ito cells	23 NX
Liver	23 NX

Kupffer cells	57 NX
Liver	57 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	22 NX
Testis	22 NX

Macrophages	57 NX
Prostate	414 NX
Skin	342 NX
Lung	49 NX
Kidney	41 NX
Testis	35 NX
Pancreas	16 NX

Melanocytes	52 NX
Skin	52 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	303 NX
Pancreas	303 NX

Mucus-secreting cells	37 NX
Colon	46 NX
Rectum	38 NX
Small intestine	31 NX

Muller glia cells	10 NX
Eye	10 NX

Pancreatic endocrine cells	40 NX
Pancreas	40 NX

Paneth cells	27 NX
Colon	29 NX
Rectum	27 NX
Small intestine	18 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	21 NX
Kidney	21 NX

Rod photoreceptor cells	7 NX
Eye	7 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	62 NX
Skin	119 NX
Prostate	62 NX
Heart muscle	17 NX
Pancreas	17 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	7 NX
Testis	7 NX

Suprabasal keratinocytes	131 NX
Skin	131 NX

Syncytiotrophoblasts	12 NX
Placenta	12 NX

T-cells	22 NX
Prostate	153 NX
Colon	85 NX
Skin	81 NX
Lung	29 NX
Liver	19 NX
Kidney	17 NX

Undifferentiated cells	32 NX
Rectum	32 NX
Small intestine	32 NX
Colon	26 NX

Urothelial cells	75 NX
Prostate	75 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.