Cell type atlas - DUSP3 - The Human Protein Atlas

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DUSP3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DUSP3
Gene descriptionⁱ Full gene name according to HGNC.	Dual specificity phosphatase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	17 NX
Lung	17 NX

B-cells	7 NX
Kidney	18 NX
Colon	13 NX
Liver	1 NX

Basal glandular cells	43 NX
Prostate	43 NX

Basal keratinocytes	20 NX
Skin	20 NX

Bipolar cells	16 NX
Eye	16 NX

Cardiomyocytes	242 NX
Heart muscle	242 NX

Cholangiocytes	48 NX
Liver	48 NX

Ciliated cells	15 NX
Lung	15 NX

Club cells	9 NX
Lung	9 NX

Collecting duct cells	40 NX
Kidney	40 NX

Cone photoreceptor cells	24 NX
Eye	24 NX

Cytotrophoblasts	14 NX
Placenta	14 NX

Distal tubular cells	35 NX
Kidney	35 NX

Ductal cells	43 NX
Pancreas	43 NX

Early spermatids	74 NX
Testis	74 NX

Endothelial cells	32 NX
Prostate	58 NX
Placenta	45 NX
Heart muscle	41 NX
Testis	37 NX
Skin	35 NX
Lung	32 NX
Liver	25 NX
Eye	17 NX
Pancreas	7 NX

Enterocytes	42 NX
Small intestine	48 NX
Rectum	43 NX
Colon	22 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	51 NX
Pancreas	51 NX

Extravillous trophoblasts	18 NX
Placenta	18 NX

Fibroblasts	18 NX
Heart muscle	80 NX
Prostate	40 NX
Skin	21 NX
Lung	18 NX
Placenta	17 NX

Glandular cells	41 NX
Prostate	41 NX

Granulocytes	38 NX
Colon	46 NX
Lung	30 NX

Hepatocytes	99 NX
Liver	99 NX

Hofbauer cells	73 NX
Placenta	73 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	35 NX
Colon	44 NX
Rectum	26 NX

Ito cells	28 NX
Liver	28 NX

Kupffer cells	35 NX
Liver	35 NX

Late spermatids	128 NX
Testis	128 NX

Leydig cells	14 NX
Testis	14 NX

Macrophages	40 NX
Prostate	54 NX
Testis	47 NX
Lung	41 NX
Skin	40 NX
Kidney	32 NX
Pancreas	21 NX

Melanocytes	10 NX
Skin	10 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	33 NX
Pancreas	33 NX

Mucus-secreting cells	18 NX
Colon	19 NX
Rectum	18 NX
Small intestine	16 NX

Muller glia cells	15 NX
Eye	15 NX

Pancreatic endocrine cells	50 NX
Pancreas	50 NX

Paneth cells	28 NX
Small intestine	49 NX
Rectum	28 NX
Colon	12 NX

Peritubular cells	25 NX
Testis	25 NX

Proximal tubular cells	69 NX
Kidney	69 NX

Rod photoreceptor cells	17 NX
Eye	17 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	36 NX
Heart muscle	59 NX
Prostate	50 NX
Pancreas	36 NX
Skin	24 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	3 NX
Testis	3 NX

Suprabasal keratinocytes	25 NX
Skin	25 NX

Syncytiotrophoblasts	38 NX
Placenta	38 NX

T-cells	6 NX
Prostate	13 NX
Kidney	12 NX
Colon	11 NX
Skin	9 NX
Lung	4 NX
Liver	1 NX

Undifferentiated cells	15 NX
Colon	18 NX
Rectum	16 NX
Small intestine	14 NX

Urothelial cells	33 NX
Prostate	33 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.