Cell type atlas - RAB5C - The Human Protein Atlas

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RAB5C

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RAB5C
Gene descriptionⁱ Full gene name according to HGNC.	RAB5C, member RAS oncogene family
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	12 NX
Lung	12 NX

B-cells	81 NX
Kidney	103 NX
Colon	91 NX
Liver	62 NX

Basal glandular cells	73 NX
Prostate	73 NX

Basal keratinocytes	99 NX
Skin	99 NX

Bipolar cells	47 NX
Eye	47 NX

Cardiomyocytes	5 NX
Heart muscle	5 NX

Cholangiocytes	61 NX
Liver	61 NX

Ciliated cells	3 NX
Lung	3 NX

Club cells	6 NX
Lung	6 NX

Collecting duct cells	101 NX
Kidney	101 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	161 NX
Placenta	161 NX

Distal tubular cells	214 NX
Kidney	214 NX

Ductal cells	165 NX
Pancreas	165 NX

Early spermatids	52 NX
Testis	52 NX

Endothelial cells	129 NX
Pancreas	312 NX
Placenta	184 NX
Skin	164 NX
Prostate	152 NX
Eye	129 NX
Testis	125 NX
Liver	108 NX
Lung	26 NX
Heart muscle	15 NX

Enterocytes	181 NX
Small intestine	200 NX
Rectum	170 NX
Colon	146 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	153 NX
Pancreas	153 NX

Extravillous trophoblasts	171 NX
Placenta	171 NX

Fibroblasts	104 NX
Placenta	110 NX
Skin	107 NX
Prostate	83 NX
Heart muscle	17 NX
Lung	14 NX

Glandular cells	89 NX
Prostate	89 NX

Granulocytes	44 NX
Colon	55 NX
Lung	33 NX

Hepatocytes	54 NX
Liver	54 NX

Hofbauer cells	378 NX
Placenta	378 NX

Horizontal cells	37 NX
Eye	37 NX

Intestinal endocrine cells	76 NX
Rectum	87 NX
Colon	65 NX

Ito cells	133 NX
Liver	133 NX

Kupffer cells	165 NX
Liver	165 NX

Late spermatids	69 NX
Testis	69 NX

Leydig cells	101 NX
Testis	101 NX

Macrophages	188 NX
Pancreas	332 NX
Kidney	200 NX
Skin	194 NX
Prostate	185 NX
Testis	180 NX
Lung	25 NX

Melanocytes	150 NX
Skin	150 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	270 NX
Pancreas	270 NX

Mucus-secreting cells	98 NX
Small intestine	134 NX
Colon	104 NX
Rectum	81 NX

Muller glia cells	93 NX
Eye	93 NX

Pancreatic endocrine cells	185 NX
Pancreas	185 NX

Paneth cells	165 NX
Colon	236 NX
Small intestine	165 NX
Rectum	111 NX

Peritubular cells	146 NX
Testis	146 NX

Proximal tubular cells	237 NX
Kidney	237 NX

Rod photoreceptor cells	32 NX
Eye	32 NX

Sertoli cells	129 NX
Testis	129 NX

Smooth muscle cells	95 NX
Pancreas	207 NX
Prostate	98 NX
Skin	89 NX
Heart muscle	13 NX

Spermatocytes	28 NX
Testis	28 NX

Spermatogonia	53 NX
Testis	53 NX

Suprabasal keratinocytes	114 NX
Skin	114 NX

Syncytiotrophoblasts	230 NX
Placenta	230 NX

T-cells	107 NX
Kidney	119 NX
Colon	111 NX
Liver	108 NX
Skin	107 NX
Prostate	44 NX
Lung	19 NX

Undifferentiated cells	89 NX
Colon	101 NX
Small intestine	95 NX
Rectum	73 NX

Urothelial cells	115 NX
Prostate	115 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.