Cell type atlas - CPD - The Human Protein Atlas

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CPD

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CPD
Gene descriptionⁱ Full gene name according to HGNC.	Carboxypeptidase D
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cholangiocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cholangiocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	19 NX
Lung	19 NX

B-cells	8 NX
Colon	11 NX
Liver	8 NX
Kidney	5 NX

Basal glandular cells	28 NX
Prostate	28 NX

Basal keratinocytes	20 NX
Skin	20 NX

Bipolar cells	23 NX
Eye	23 NX

Cardiomyocytes	10 NX
Heart muscle	10 NX

Cholangiocytes	178 NX
Liver	178 NX

Ciliated cells	19 NX
Lung	19 NX

Club cells	27 NX
Lung	27 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	43 NX
Eye	43 NX

Cytotrophoblasts	21 NX
Placenta	21 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	21 NX
Pancreas	21 NX

Early spermatids	76 NX
Testis	76 NX

Endothelial cells	48 NX
Liver	85 NX
Prostate	58 NX
Heart muscle	57 NX
Testis	50 NX
Eye	47 NX
Skin	46 NX
Lung	32 NX
Placenta	26 NX
Pancreas	0 NX

Enterocytes	32 NX
Rectum	43 NX
Small intestine	40 NX
Colon	22 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	21 NX
Pancreas	21 NX

Extravillous trophoblasts	9 NX
Placenta	9 NX

Fibroblasts	26 NX
Prostate	42 NX
Skin	31 NX
Placenta	23 NX
Lung	19 NX
Heart muscle	12 NX

Glandular cells	59 NX
Prostate	59 NX

Granulocytes	24 NX
Colon	37 NX
Lung	12 NX

Hepatocytes	67 NX
Liver	67 NX

Hofbauer cells	15 NX
Placenta	15 NX

Horizontal cells	45 NX
Eye	45 NX

Intestinal endocrine cells	31 NX
Colon	34 NX
Rectum	28 NX

Ito cells	51 NX
Liver	51 NX

Kupffer cells	35 NX
Liver	35 NX

Late spermatids	42 NX
Testis	42 NX

Leydig cells	16 NX
Testis	16 NX

Macrophages	21 NX
Prostate	37 NX
Kidney	23 NX
Lung	23 NX
Pancreas	16 NX
Skin	15 NX
Testis	10 NX

Melanocytes	29 NX
Skin	29 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	10 NX
Pancreas	10 NX

Mucus-secreting cells	69 NX
Small intestine	87 NX
Rectum	80 NX
Colon	33 NX

Muller glia cells	11 NX
Eye	11 NX

Pancreatic endocrine cells	30 NX
Pancreas	30 NX

Paneth cells	20 NX
Rectum	34 NX
Colon	20 NX
Small intestine	18 NX

Peritubular cells	15 NX
Testis	15 NX

Proximal tubular cells	18 NX
Kidney	18 NX

Rod photoreceptor cells	35 NX
Eye	35 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	23 NX
Prostate	39 NX
Skin	24 NX
Heart muscle	13 NX
Pancreas	11 NX

Spermatocytes	16 NX
Testis	16 NX

Spermatogonia	24 NX
Testis	24 NX

Suprabasal keratinocytes	16 NX
Skin	16 NX

Syncytiotrophoblasts	20 NX
Placenta	20 NX

T-cells	21 NX
Colon	49 NX
Prostate	48 NX
Skin	33 NX
Liver	21 NX
Kidney	15 NX
Lung	7 NX

Undifferentiated cells	32 NX
Rectum	39 NX
Small intestine	22 NX
Colon	22 NX

Urothelial cells	39 NX
Prostate	39 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.