Cell type atlas - CBX1 - The Human Protein Atlas

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CBX1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CBX1
Gene descriptionⁱ Full gene name according to HGNC.	Chromobox 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes, Spermatogonia)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes, Spermatogonia)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	63 NX
Lung	63 NX

Alveolar cells type 2	22 NX
Lung	22 NX

B-cells	27 NX
Kidney	54 NX
Colon	31 NX
Liver	11 NX

Basal glandular cells	29 NX
Prostate	29 NX

Basal keratinocytes	39 NX
Skin	39 NX

Bipolar cells	41 NX
Eye	41 NX

Cardiomyocytes	65 NX
Heart muscle	65 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	44 NX
Lung	44 NX

Club cells	38 NX
Lung	38 NX

Collecting duct cells	40 NX
Kidney	40 NX

Cone photoreceptor cells	20 NX
Eye	20 NX

Cytotrophoblasts	48 NX
Placenta	48 NX

Distal tubular cells	30 NX
Kidney	30 NX

Ductal cells	62 NX
Pancreas	62 NX

Early spermatids	25 NX
Testis	25 NX

Endothelial cells	38 NX
Heart muscle	58 NX
Pancreas	57 NX
Testis	47 NX
Placenta	41 NX
Lung	38 NX
Eye	26 NX
Skin	25 NX
Prostate	25 NX
Liver	16 NX

Enterocytes	10 NX
Rectum	16 NX
Colon	12 NX
Small intestine	8 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	26 NX
Pancreas	26 NX

Extravillous trophoblasts	69 NX
Placenta	69 NX

Fibroblasts	49 NX
Heart muscle	89 NX
Lung	82 NX
Placenta	52 NX
Prostate	46 NX
Skin	40 NX

Glandular cells	26 NX
Prostate	26 NX

Granulocytes	38 NX
Lung	49 NX
Colon	28 NX

Hepatocytes	15 NX
Liver	15 NX

Hofbauer cells	56 NX
Placenta	56 NX

Horizontal cells	48 NX
Eye	48 NX

Intestinal endocrine cells	39 NX
Rectum	54 NX
Colon	24 NX

Ito cells	21 NX
Liver	21 NX

Kupffer cells	29 NX
Liver	29 NX

Late spermatids	41 NX
Testis	41 NX

Leydig cells	74 NX
Testis	74 NX

Macrophages	25 NX
Testis	40 NX
Pancreas	28 NX
Lung	25 NX
Skin	25 NX
Prostate	19 NX
Kidney	17 NX

Melanocytes	39 NX
Skin	39 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	51 NX
Pancreas	51 NX

Mucus-secreting cells	25 NX
Colon	28 NX
Rectum	23 NX
Small intestine	18 NX

Muller glia cells	84 NX
Eye	84 NX

Pancreatic endocrine cells	31 NX
Pancreas	31 NX

Paneth cells	7 NX
Rectum	22 NX
Small intestine	7 NX
Colon	6 NX

Peritubular cells	86 NX
Testis	86 NX

Proximal tubular cells	22 NX
Kidney	22 NX

Rod photoreceptor cells	32 NX
Eye	32 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	34 NX
Pancreas	73 NX
Heart muscle	70 NX
Skin	29 NX
Prostate	27 NX

Spermatocytes	239 NX
Testis	239 NX

Spermatogonia	236 NX
Testis	236 NX

Suprabasal keratinocytes	32 NX
Skin	32 NX

Syncytiotrophoblasts	23 NX
Placenta	23 NX

T-cells	22 NX
Lung	33 NX
Kidney	33 NX
Skin	23 NX
Colon	22 NX
Liver	15 NX
Prostate	13 NX

Undifferentiated cells	29 NX
Small intestine	31 NX
Rectum	23 NX
Colon	20 NX

Urothelial cells	18 NX
Prostate	18 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.