Cell type atlas - CDK5RAP3 - The Human Protein Atlas

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CDK5RAP3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CDK5RAP3
Gene descriptionⁱ Full gene name according to HGNC.	CDK5 regulatory subunit associated protein 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	60 NX
Lung	60 NX

B-cells	44 NX
Kidney	45 NX
Colon	43 NX
Liver	30 NX

Basal glandular cells	57 NX
Prostate	57 NX

Basal keratinocytes	30 NX
Skin	30 NX

Bipolar cells	51 NX
Eye	51 NX

Cardiomyocytes	22 NX
Heart muscle	22 NX

Cholangiocytes	54 NX
Liver	54 NX

Ciliated cells	68 NX
Lung	68 NX

Club cells	55 NX
Lung	55 NX

Collecting duct cells	38 NX
Kidney	38 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	59 NX
Placenta	59 NX

Distal tubular cells	43 NX
Kidney	43 NX

Ductal cells	47 NX
Pancreas	47 NX

Early spermatids	30 NX
Testis	30 NX

Endothelial cells	32 NX
Lung	44 NX
Heart muscle	41 NX
Placenta	40 NX
Eye	32 NX
Testis	32 NX
Skin	25 NX
Prostate	23 NX
Liver	16 NX
Pancreas	14 NX

Enterocytes	56 NX
Small intestine	60 NX
Colon	56 NX
Rectum	34 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	59 NX
Pancreas	59 NX

Extravillous trophoblasts	47 NX
Placenta	47 NX

Fibroblasts	41 NX
Placenta	53 NX
Lung	50 NX
Heart muscle	41 NX
Skin	34 NX
Prostate	26 NX

Glandular cells	53 NX
Prostate	53 NX

Granulocytes	67 NX
Lung	79 NX
Colon	55 NX

Hepatocytes	48 NX
Liver	48 NX

Hofbauer cells	55 NX
Placenta	55 NX

Horizontal cells	54 NX
Eye	54 NX

Intestinal endocrine cells	59 NX
Colon	71 NX
Rectum	47 NX

Ito cells	22 NX
Liver	22 NX

Kupffer cells	38 NX
Liver	38 NX

Late spermatids	30 NX
Testis	30 NX

Leydig cells	38 NX
Testis	38 NX

Macrophages	41 NX
Lung	73 NX
Skin	45 NX
Kidney	45 NX
Pancreas	37 NX
Prostate	29 NX
Testis	26 NX

Melanocytes	44 NX
Skin	44 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	49 NX
Pancreas	49 NX

Mucus-secreting cells	50 NX
Colon	84 NX
Small intestine	64 NX
Rectum	46 NX

Muller glia cells	45 NX
Eye	45 NX

Pancreatic endocrine cells	37 NX
Pancreas	37 NX

Paneth cells	56 NX
Colon	66 NX
Small intestine	56 NX
Rectum	42 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	40 NX
Kidney	40 NX

Rod photoreceptor cells	51 NX
Eye	51 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	29 NX
Skin	39 NX
Pancreas	29 NX
Heart muscle	26 NX
Prostate	25 NX

Spermatocytes	72 NX
Testis	72 NX

Spermatogonia	40 NX
Testis	40 NX

Suprabasal keratinocytes	23 NX
Skin	23 NX

Syncytiotrophoblasts	52 NX
Placenta	52 NX

T-cells	52 NX
Lung	117 NX
Liver	62 NX
Colon	52 NX
Skin	47 NX
Kidney	46 NX
Prostate	26 NX

Undifferentiated cells	48 NX
Colon	53 NX
Small intestine	49 NX
Rectum	47 NX

Urothelial cells	51 NX
Prostate	51 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.