Cell type atlas - PPIF - The Human Protein Atlas

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PPIF

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPIF
Gene descriptionⁱ Full gene name according to HGNC.	Peptidylprolyl isomerase F
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	5 NX
Lung	5 NX

B-cells	34 NX
Colon	72 NX
Liver	34 NX
Kidney	13 NX

Basal glandular cells	26 NX
Prostate	26 NX

Basal keratinocytes	38 NX
Skin	38 NX

Bipolar cells	4 NX
Eye	4 NX

Cardiomyocytes	106 NX
Heart muscle	106 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	12 NX
Lung	12 NX

Club cells	9 NX
Lung	9 NX

Collecting duct cells	12 NX
Kidney	12 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	70 NX
Placenta	70 NX

Distal tubular cells	78 NX
Kidney	78 NX

Ductal cells	38 NX
Pancreas	38 NX

Early spermatids	11 NX
Testis	11 NX

Endothelial cells	14 NX
Prostate	22 NX
Skin	20 NX
Heart muscle	14 NX
Pancreas	14 NX
Eye	8 NX
Liver	7 NX
Placenta	7 NX
Testis	3 NX
Lung	0 NX

Enterocytes	22 NX
Rectum	29 NX
Colon	22 NX
Small intestine	20 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	24 NX
Pancreas	24 NX

Extravillous trophoblasts	113 NX
Placenta	113 NX

Fibroblasts	24 NX
Placenta	35 NX
Heart muscle	28 NX
Prostate	24 NX
Skin	22 NX
Lung	21 NX

Glandular cells	17 NX
Prostate	17 NX

Granulocytes	14 NX
Colon	28 NX
Lung	0 NX

Hepatocytes	70 NX
Liver	70 NX

Hofbauer cells	83 NX
Placenta	83 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	21 NX
Rectum	21 NX
Colon	20 NX

Ito cells	9 NX
Liver	9 NX

Kupffer cells	32 NX
Liver	32 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	6 NX
Testis	6 NX

Macrophages	60 NX
Skin	202 NX
Prostate	168 NX
Pancreas	75 NX
Lung	59 NX
Kidney	46 NX
Testis	16 NX

Melanocytes	34 NX
Skin	34 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	33 NX
Pancreas	33 NX

Mucus-secreting cells	62 NX
Colon	80 NX
Rectum	61 NX
Small intestine	40 NX

Muller glia cells	10 NX
Eye	10 NX

Pancreatic endocrine cells	40 NX
Pancreas	40 NX

Paneth cells	18 NX
Rectum	37 NX
Small intestine	18 NX
Colon	17 NX

Peritubular cells	6 NX
Testis	6 NX

Proximal tubular cells	31 NX
Kidney	31 NX

Rod photoreceptor cells	5 NX
Eye	5 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	24 NX
Pancreas	54 NX
Prostate	37 NX
Heart muscle	24 NX
Skin	20 NX

Spermatocytes	7 NX
Testis	7 NX

Spermatogonia	22 NX
Testis	22 NX

Suprabasal keratinocytes	33 NX
Skin	33 NX

Syncytiotrophoblasts	119 NX
Placenta	119 NX

T-cells	18 NX
Colon	48 NX
Skin	23 NX
Prostate	18 NX
Liver	16 NX
Kidney	15 NX
Lung	4 NX

Undifferentiated cells	64 NX
Colon	98 NX
Rectum	62 NX
Small intestine	61 NX

Urothelial cells	29 NX
Prostate	29 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.